MAGNETIC BOARD QUIZ

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Medications and Human Milk quiz game

Type of holiday

Parts of the body

Routes of drug administration

What are Enteral, Sublingual, Inhalation, Parenteral and subcutaneous?

Question 1/10

Methods of feeding

Next

Different types of drug andministration can impact how much drug passes into the human milk and reach the baby

Right!

Because baby has big tongue to absorbe the drug

Because all the drugs that pass into the human milk, are transferred to the baby orally

Because high oral bioavalability means that the mouth absorbes the drug

A drug with high oral bioavalability is more likely to reach the newborn circulation and be absorbed. Why?

Question 2/10

Because the baby's GI is immature

Next

Oral Biovalability means a drug is able to mantain its farmacological proprerties when passing the GI tract. All the drugs transferred to baby pass the GI tract with human milk.

RIGHT!

Before lactogenesis II because junctions among lactocytes are wider

During galactopoiesis (lactogenesis III)

When mum is dihydrated because blood is more concentrated

Passive diffusion is the most common mechanism of transfer for drugs from bloodstream to milk. When can passive diffusion happen more easily?

Question 3/10

After a c/section beacause mum receives more drugs

Next

Closure of tight junctures among cells happens around 36 hrs post delivery (lactogenesis II). With closure, transfer is greatly reduced

Right!

Pump diffusion

Active diffusion

Milk transfer

Milk/Plasma ratio

If maternal plasma levels increase so does the concentration in the HM. As soon as the maternal plasma level has fallen, the milk level soon follows. How is this property called?

Question 4/10

Next

Milk/ plasma ratio. If high (> 1-5), it is useful as an indicator of drugs that may sequester in milk in high levels. If low (<1), it is good indicator that only minimal levels of the drug are transferred into milk.

RIGHT!

Yes, the larger is the molecular weight the easier can pass into the human milk

No, the molecular weight doesn't have an impact on the transfer

Molecular weight is derectly proportional to transfer into human milk

Do you think the drug molecolar weight has an impact on its ability to be transfered into human milk?

Question 5/10

Yes, the smaller is the molecole weight the easier can pass into human milk

Next

The smaller the molecular weight (< 300 Daltons) the easier is the rate of diffusion across the layer lipid membrane of the lactocytes.

Right!

The more lipid soluble the medication is the more it will transfer into HM

Lipid suluble drugs easily dissolve into plasma

Triglicerides will transfer from HM to plasma

Plasma concentrations of lipids is very low compared to 5-15% of triglycerides found in HM. Knowing this statament which sentence do you think is true?

Question 6/10

Triglicerids makes difficult the diffusion of drug in HM

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The more lipid soluble is the medication and the more it will transfer into HM

RIGHT!

It doesn't matter as it doesn't impact on the transfer into HM

The bound with a protein makes more difficult transfer into HM

If bound with a protein the drug molecule can easily pass into HM

Why the protein binding of the medication is an important factor to consider when evaluate prescription of a medication during breastfeeding?

Question 7/10

Binding with a protein inactivate the drug molecule

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Free unbound drug diffuses readily, while highly protein-bound drugs like are unable to diffuse in significant amounts in HM

RIGHT!

Time of elimination of a drug

Dose of the drug that is terapeutic in pregnant women

Way of administration of a drug

Pharmacogenomics is:

Question 8/10

The study of how genes affect a person's response to drugs

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People metabolise drungs in different way due to different genes activity.

RIght!

Drugs with short half life are more likely to be trasferred into HM

Because they get absorbed by fat tissue

Because they stay into the maternal body for longer

Why drugs with long half life are more likely to be found into HM?

Question 9/10

Because maternal body doesn't absorbe the drug

Next

The shorter the better: a short half life means that the drug stays in the plasma and in the HM for less time and it is eliminated by the baby’s body more quickly

RIGHT!

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