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ESC-HF 2026 ATTR-CM

Iridium CE

Created on June 17, 2026

Explore the latest evidence in hereditary ATTR-CM through expert faculty insights, interactive knowledge checks, and an AI-guided patient case. Strengthen diagnostic, genetic screening, and treatment decision-making using emerging ESC Heart Failure 2026 data.

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Podium to Practice: ATTR-CM in Women

What ACC.26 Means for Your Practice

Identify | Diagnose | Treat

The women with ATTR-CM who may be missed in clinical practice

Start

CME Information

Part 1 of a 4-part Congress Series

  • Bulleted list
  • Bulleted list
Translating congress updates into clinical practice.

ATTR-CM in Women

ACC.26 Congress Coverage

June 2026

p.Val142IleVariant

ESC Heart Failure 2026

Nov 2026

ATTR-CM & Arrhythmia

ESC Congress 2026 & HFSA 2026

Feb 2027

Year in Review Capstone

AHA Scientific Sessions 2026 & ISA 2026

Subtitle

This educational activity is supported by an independent educational grant from BridgeBio Pharma, Inc.

Part 1 of a 4-part Congress Series

Translating congress updates into clinical practice.

ATTR-CM in Women

ACC.26 Congress Coverage

ATTR-CM in Women

ACC.26 Congress Coverage

Nov 2026

ATTR-CM & Arrhythmia

ESC Congress 2026 & HFSA 2026

Feb 2027

Year in Review Capstone

AHA Scientific Sessions 2026 & ISA 2026

Meet today's Faculty, Pooja Prasad, MD

Assistant Clinical Professor Advanced Heart Failure & Transplant Cardiology | Pulmonary Hypertension University of California, San Francisco San Francisco, CA Nothing to disclose

Program Overview

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ACC.26 ATTR-CM: At a Glance

Griffin JM et al. ACC.26 Poster 1379-169 "Association Between Early Increase in sTTR with Acoramidis and Long-Term Effects on Heart Failure-Related Health Status in ATTR-CM" | Waldron J et al. ACC.26 Poster "Treatment Patterns and Preferences in ATTR-CM in the United States: Results from a Real-World Survey" | Ozbey O et al. ACC.26 Abstract 26-A-14031 "Sex-Specific Phenotype Analysis in ATTR-CM" | Soman P et al. ACC.26 Late-Breaking Oral "Long-Term Efficacy and Safety of Acoramidis: 54-Month Open-Label Extension Results" | Fontana M et al. NEJM 2025;392:33-44 + HELIOS-B 48-mo OLE + CMR data (AHA 2025) | Maurer MS et al. NEJM 2018;379:1007-1016 + ATTR-ACT 60-mo OLE & ACC.26 octogenarian RWD | ACC.26 Conference Abstracts, New Orleans, March 28-30, 2026

ACC.26 ATTR-CM: At a Glance

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This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

Griffin JM et al. ACC.26 Poster 1379-169 "Association Between Early Increase in sTTR with Acoramidis and Long-Term Effects on Heart Failure-Related Health Status in ATTR-CM" | Waldron J et al. ACC.26 Poster "Treatment Patterns and Preferences in ATTR-CM in the United States: Results from a Real-World Survey" | Ozbey O et al. ACC.26 Abstract 26-A-14031 "Sex-Specific Phenotype Analysis in ATTR-CM" | Soman P et al. ACC.26 Late-Breaking Oral "Long-Term Efficacy and Safety of Acoramidis: 54-Month Open-Label Extension Results" | Fontana M et al. NEJM 2025;392:33-44 + HELIOS-B 48-mo OLE + CMR data (AHA 2025) | Maurer MS et al. NEJM 2018;379:1007-1016 + ATTR-ACT 60-mo OLE & ACC.26 octogenarian RWD | ACC.26 Conference Abstracts, New Orleans, March 28-30, 2026

ACC.26 ATTR-CM: At a Glance

ACC.26 ATTR-CM: At a Glance

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This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

Griffin JM et al. ACC.26 Poster 1379-169 "Association Between Early Increase in sTTR with Acoramidis and Long-Term Effects on Heart Failure-Related Health Status in ATTR-CM" | Waldron J et al. ACC.26 Poster "Treatment Patterns and Preferences in ATTR-CM in the United States: Results from a Real-World Survey" | Ozbey O et al. ACC.26 Abstract 26-A-14031 "Sex-Specific Phenotype Analysis in ATTR-CM" | Soman P et al. ACC.26 Late-Breaking Oral "Long-Term Efficacy and Safety of Acoramidis: 54-Month Open-Label Extension Results" | Fontana M et al. NEJM 2025;392:33-44 + HELIOS-B 48-mo OLE + CMR data (AHA 2025) | Maurer MS et al. NEJM 2018;379:1007-1016 + ATTR-ACT 60-mo OLE & ACC.26 octogenarian RWD | ACC.26 Conference Abstracts, New Orleans, March 28-30, 2026

ACC.26 ATTR-CM: At a Glance

ACC.26 ATTR-CM: At a Glance

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

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Time Since Randomization (months)

Time Since Randomization (months)

Time Since Randomization (months)

Time Since Randomization (months)

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Griffin JM et al. ACC.26 Poster 1379-169 "Association Between Early Increase in sTTR with Acoramidis and Long-Term Effects on Heart Failure-Related Health Status in ATTR-CM" | Waldron J et al. ACC.26 Poster "Treatment Patterns and Preferences in ATTR-CM in the United States: Results from a Real-World Survey" | Ozbey O et al. ACC.26 Abstract 26-A-14031 "Sex-Specific Phenotype Analysis in ATTR-CM" | Soman P et al. ACC.26 Late-Breaking Oral "Long-Term Efficacy and Safety of Acoramidis: 54-Month Open-Label Extension Results" | Fontana M et al. NEJM 2025;392:33-44 + HELIOS-B 48-mo OLE + CMR data (AHA 2025) | Maurer MS et al. NEJM 2018;379:1007-1016 + ATTR-ACT 60-mo OLE & ACC.26 octogenarian RWD | ACC.26 Conference Abstracts, New Orleans, March 28-30, 2026

ACC.26 ATTR-CM: At a Glance

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

Continuous

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Time Since Randomization (months)

Time Since Randomization (months)

Griffin JM et al. ACC.26 Poster 1379-169 "Association Between Early Increase in sTTR with Acoramidis and Long-Term Effects on Heart Failure-Related Health Status in ATTR-CM" | Waldron J et al. ACC.26 Poster "Treatment Patterns and Preferences in ATTR-CM in the United States: Results from a Real-World Survey" | Ozbey O et al. ACC.26 Abstract 26-A-14031 "Sex-Specific Phenotype Analysis in ATTR-CM" | Soman P et al. ACC.26 Late-Breaking Oral "Long-Term Efficacy and Safety of Acoramidis: 54-Month Open-Label Extension Results" | Fontana M et al. NEJM 2025;392:33-44 + HELIOS-B 48-mo OLE + CMR data (AHA 2025) | Maurer MS et al. NEJM 2018;379:1007-1016 + ATTR-ACT 60-mo OLE & ACC.26 octogenarian RWD | ACC.26 Conference Abstracts, New Orleans, March 28-30, 2026

Griffin JM et al. ACC.26 Poster 1379-169 "Association Between Early Increase in sTTR with Acoramidis and Long-Term Effects on Heart Failure-Related Health Status in ATTR-CM" | Waldron J et al. ACC.26 Poster "Treatment Patterns and Preferences in ATTR-CM in the United States: Results from a Real-World Survey" | Ozbey O et al. ACC.26 Abstract 26-A-14031 "Sex-Specific Phenotype Analysis in ATTR-CM" | Soman P et al. ACC.26 Late-Breaking Oral "Long-Term Efficacy and Safety of Acoramidis: 54-Month Open-Label Extension Results" | Fontana M et al. NEJM 2025;392:33-44 + HELIOS-B 48-mo OLE + CMR data (AHA 2025) | Maurer MS et al. NEJM 2018;379:1007-1016 + ATTR-ACT 60-mo OLE & ACC.26 octogenarian RWD | ACC.26 Conference Abstracts, New Orleans, March 28-30, 2026

ACC.26 ATTR-CM: At a Glance

ACC.26 ATTR-CM: At a Glance

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

Time Since Randomization (months)

Griffin JM et al. ACC.26 Poster 1379-169 "Association Between Early Increase in sTTR with Acoramidis and Long-Term Effects on Heart Failure-Related Health Status in ATTR-CM" | Waldron J et al. ACC.26 Poster "Treatment Patterns and Preferences in ATTR-CM in the United States: Results from a Real-World Survey" | Ozbey O et al. ACC.26 Abstract 26-A-14031 "Sex-Specific Phenotype Analysis in ATTR-CM" | Soman P et al. ACC.26 Late-Breaking Oral "Long-Term Efficacy and Safety of Acoramidis: 54-Month Open-Label Extension Results" | Fontana M et al. NEJM 2025;392:33-44 + HELIOS-B 48-mo OLE + CMR data (AHA 2025) | Maurer MS et al. NEJM 2018;379:1007-1016 + ATTR-ACT 60-mo OLE & ACC.26 octogenarian RWD | ACC.26 Conference Abstracts, New Orleans, March 28-30, 2026

Griffin JM et al. ACC.26 Poster 1379-169 "Association Between Early Increase in sTTR with Acoramidis and Long-Term Effects on Heart Failure-Related Health Status in ATTR-CM" | Waldron J et al. ACC.26 Poster "Treatment Patterns and Preferences in ATTR-CM in the United States: Results from a Real-World Survey" | Ozbey O et al. ACC.26 Abstract 26-A-14031 "Sex-Specific Phenotype Analysis in ATTR-CM" | Soman P et al. ACC.26 Late-Breaking Oral "Long-Term Efficacy and Safety of Acoramidis: 54-Month Open-Label Extension Results" | Fontana M et al. NEJM 2025;392:33-44 + HELIOS-B 48-mo OLE + CMR data (AHA 2025) | Maurer MS et al. NEJM 2018;379:1007-1016 + ATTR-ACT 60-mo OLE & ACC.26 octogenarian RWD | ACC.26 Conference Abstracts, New Orleans, March 28-30, 2026

Clinical Challenge

ACC.26 ATTR-CM: At a Glance

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This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

Continuous

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Time Since Randomization (months)

Time Since Randomization (months)

Time Since Randomization (months)

Griffin JM et al. ACC.26 Poster 1379-169 "Association Between Early Increase in sTTR with Acoramidis and Long-Term Effects on Heart Failure-Related Health Status in ATTR-CM" | Waldron J et al. ACC.26 Poster "Treatment Patterns and Preferences in ATTR-CM in the United States: Results from a Real-World Survey" | Ozbey O et al. ACC.26 Abstract 26-A-14031 "Sex-Specific Phenotype Analysis in ATTR-CM" | Soman P et al. ACC.26 Late-Breaking Oral "Long-Term Efficacy and Safety of Acoramidis: 54-Month Open-Label Extension Results" | Fontana M et al. NEJM 2025;392:33-44 + HELIOS-B 48-mo OLE + CMR data (AHA 2025) | Maurer MS et al. NEJM 2018;379:1007-1016 + ATTR-ACT 60-mo OLE & ACC.26 octogenarian RWD | ACC.26 Conference Abstracts, New Orleans, March 28-30, 2026

ACC.26 ATTR-CM: At a Glance

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This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

Continuous

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Time Since Randomization (months)

Time Since Randomization (months)

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Griffin JM et al. ACC.26 Poster 1379-169 "Association Between Early Increase in sTTR with Acoramidis and Long-Term Effects on Heart Failure-Related Health Status in ATTR-CM" | Waldron J et al. ACC.26 Poster "Treatment Patterns and Preferences in ATTR-CM in the United States: Results from a Real-World Survey" | Ozbey O et al. ACC.26 Abstract 26-A-14031 "Sex-Specific Phenotype Analysis in ATTR-CM" | Soman P et al. ACC.26 Late-Breaking Oral "Long-Term Efficacy and Safety of Acoramidis: 54-Month Open-Label Extension Results" | Fontana M et al. NEJM 2025;392:33-44 + HELIOS-B 48-mo OLE + CMR data (AHA 2025) | Maurer MS et al. NEJM 2018;379:1007-1016 + ATTR-ACT 60-mo OLE & ACC.26 octogenarian RWD | ACC.26 Conference Abstracts, New Orleans, March 28-30, 2026

ACC.26 ATTR-CM: At a Glance

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This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

Time Since Randomization (months)

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

Griffin JM et al. ACC.26 Poster 1379-169 "Association Between Early Increase in sTTR with Acoramidis and Long-Term Effects on Heart Failure-Related Health Status in ATTR-CM" | Waldron J et al. ACC.26 Poster "Treatment Patterns and Preferences in ATTR-CM in the United States: Results from a Real-World Survey" | Ozbey O et al. ACC.26 Abstract 26-A-14031 "Sex-Specific Phenotype Analysis in ATTR-CM" | Soman P et al. ACC.26 Late-Breaking Oral "Long-Term Efficacy and Safety of Acoramidis: 54-Month Open-Label Extension Results" | Fontana M et al. NEJM 2025;392:33-44 + HELIOS-B 48-mo OLE + CMR data (AHA 2025) | Maurer MS et al. NEJM 2018;379:1007-1016 + ATTR-ACT 60-mo OLE & ACC.26 octogenarian RWD | ACC.26 Conference Abstracts, New Orleans, March 28-30, 2026

ACC.26 ATTR-CM: At a Glance

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This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

Continuous

Continuous

Time Since Randomization (months)

Time Since Randomization (months)

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

Griffin JM et al. ACC.26 Poster 1379-169 "Association Between Early Increase in sTTR with Acoramidis and Long-Term Effects on Heart Failure-Related Health Status in ATTR-CM" | Waldron J et al. ACC.26 Poster "Treatment Patterns and Preferences in ATTR-CM in the United States: Results from a Real-World Survey" | Ozbey O et al. ACC.26 Abstract 26-A-14031 "Sex-Specific Phenotype Analysis in ATTR-CM" | Soman P et al. ACC.26 Late-Breaking Oral "Long-Term Efficacy and Safety of Acoramidis: 54-Month Open-Label Extension Results" | Fontana M et al. NEJM 2025;392:33-44 + HELIOS-B 48-mo OLE + CMR data (AHA 2025) | Maurer MS et al. NEJM 2018;379:1007-1016 + ATTR-ACT 60-mo OLE & ACC.26 octogenarian RWD | ACC.26 Conference Abstracts, New Orleans, March 28-30, 2026

Clinical Challenge

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ACC.26 ATTR-CM: At a Glance

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This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

Time Since Randomization (months)

Time Since Randomization (months)

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Griffin JM et al. ACC.26 Poster 1379-169 "Association Between Early Increase in sTTR with Acoramidis and Long-Term Effects on Heart Failure-Related Health Status in ATTR-CM" | Waldron J et al. ACC.26 Poster "Treatment Patterns and Preferences in ATTR-CM in the United States: Results from a Real-World Survey" | Ozbey O et al. ACC.26 Abstract 26-A-14031 "Sex-Specific Phenotype Analysis in ATTR-CM" | Soman P et al. ACC.26 Late-Breaking Oral "Long-Term Efficacy and Safety of Acoramidis: 54-Month Open-Label Extension Results" | Fontana M et al. NEJM 2025;392:33-44 + HELIOS-B 48-mo OLE + CMR data (AHA 2025) | Maurer MS et al. NEJM 2018;379:1007-1016 + ATTR-ACT 60-mo OLE & ACC.26 octogenarian RWD | ACC.26 Conference Abstracts, New Orleans, March 28-30, 2026

Clinical Challenge

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Diagnosis confirmed: ATTR-CM

Grade 2–3 PYP uptake

Grade 2–3 PYP uptake

Grade 2–3 PYP uptake

Grade 2–3 PYP uptake

Grade 2–3 PYP uptake

Grade 2–3 PYP uptake

Grade 2–3 PYP uptake

Grade 2–3 PYP uptake

Grade 2–3 PYP uptake

Grade 2–3 PYP uptake

Grade 2–3 PYP uptake

Grade 2–3 PYP uptake

Grade 2–3 PYP uptake

Grade 2–3 PYP uptake

Natural history: Gonzalez-Lopez E et al. PMC9700255. Disease staging: Gillmore JD et al. ESC Heart Failure 2020 (PMC7755026). Earlier diagnosis: Circulation Heart Failure 2024. CV hospitalisation: Antonopoulos AS et al. ESC Heart Failure 2026 (meta-analysis, n=5,203). Individual product labelling should be consulted.​

Diagnosis confirmed: ATTR-CM

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Clinical Challenge

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This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

This paragraph is ready to be filled with incredible creativity, experiences, and stories.

Real-world effectiveness

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Subtitle

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Subtitle

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Subtitle

Natural history: Gonzalez-Lopez E et al. PMC9700255. Disease staging: Gillmore JD et al. ESC Heart Failure 2020 (PMC7755026). Earlier diagnosis: Circulation Heart Failure 2024. CV hospitalisation: Antonopoulos AS et al. ESC Heart Failure 2026 (meta-analysis, n=5,203). Individual product labelling should be consulted.​

Clinical Challenge

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Thank You

Apply these insights in your next patient evaluation.

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