31- Inflammatory & Neuropathic Pain (4.10.26)

Pain & The BrAin-BODY COnnection

(cont'd)

4.10.26

ANNOUNCEMENTS

• Project Milestone 3 submissions
• Started providing feedback on videos submitted as a link
• Recommended to address feedback & re-record before final submission

• Exam 2 Key
• Can't be posted yet (still waiting on a makeup)
• Exam 3
• postponed until next Wed 4/15
• will cover Ch. 13 - the Body Senses

Basic pathway of Pain

Pain

• Pain - an unpleasant sensory and emotional experience associated with actual or potential tissue damage
• The perception that results from nociception

Inflammatory pain

• inflammatory pain - pain that arises when chemicals are released by damaged tissue

REFERRED pain

referred pain - sense of pain may be localized to a different part of the body than where the tissue damage occurred

Muscle FATIGUE

neuropathic pain - pain that arises when the damaged tissue is in the nervous system (central or peripheral)

Neuropathic pain

hyperalgesia

innocuous- (neutral/ otherwise harmless)

hyperalgesia - enhanced pain to a noxious stimulus (that is already normally painful)

noxious - (painful/ otherwise harmful)

Allodynia

allodynia - pain to an innocuous stimulus (that is not normally painful)

noxious - (painful/ otherwise harmful)

innocuous- (neutral/ otherwise harmless)

Hyperalgesia is a sensitization to existing pain, whereas allodynia is the emergence of new pain.

Allodynia

• enhanced mechanical reactivity
• arises from strengthening of tactile (not nociceptive) synapse.

Thanks for listening!

Reminder to complete your Exit Ticket