Updates on Sepsis Management
VECCSI 2026
Infection does not equal Sepsis
Sepsis = Infection + dysregulated immune response
Infection
Suspected or documented
Timeline
Abnormal Vitals
Scoring and Clinical Evaluation
Sepsis exists on a continuum from the initiation of infection to the development of circulatory collapse.
Systemic Inflammation
WBC, CRP, lactate, PCT
End-organ dysfunction
one or more
Hemodynamic collapse
Septic shock
Management Updates
Lactate clearance not a guide for resuscitation
Early, empiric broad-spectrum antibiotic therapy
LRS over saline, early fluid and vasopressor use
No Vit C, Albumin, Protein C, VA-ECMO
hydrocortisone CRI if pressor refractory, HYPRESS
MAP >65mmHg, NE, vasopressin, epi/ dobutamine
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Updates on Sepsis Management
Hamsini Yagneswar
Created on January 30, 2026
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Transcript
Updates on Sepsis Management
VECCSI 2026
Infection does not equal Sepsis
Sepsis = Infection + dysregulated immune response
Infection
Suspected or documented
Timeline
Abnormal Vitals
Scoring and Clinical Evaluation
Sepsis exists on a continuum from the initiation of infection to the development of circulatory collapse.
Systemic Inflammation
WBC, CRP, lactate, PCT
End-organ dysfunction
one or more
Hemodynamic collapse
Septic shock
Management Updates
Lactate clearance not a guide for resuscitation
Early, empiric broad-spectrum antibiotic therapy
LRS over saline, early fluid and vasopressor use
No Vit C, Albumin, Protein C, VA-ECMO
hydrocortisone CRI if pressor refractory, HYPRESS
MAP >65mmHg, NE, vasopressin, epi/ dobutamine
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Let the communication flow!
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Let the communication flow!
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