[MYE-0087] Myeloma Treatment Journey: From First Line to Fourth Line

Myeloma Treatment:

First Line to Fourth Line

Tap on the numbers to learn more.

SECOND-LINE THERAPY

FIRST-LINE THERAPY

FOURTH-LINE THERAPY

THIRD-LINE THERAPY

FIRST-LINE THERAPY

After you’re first diagnosed

Combination of three or four drugs including:

• Daratumumab (Darzalex)
• Bortezomib (Velcade)
• Lenalidomide (Revlimid)
• Dexamethasone
• Isatuximab-irfc (Sarclisa)
• Cyclophosphamide

If you’re eligible, your doctor might also recommend a bone marrow transplant. After first-line therapy, you’ll likely begin maintenance treatment to stay in remission.

THIRD-LINE THERAPY

After the second relapse

Depending on which drugs were used before and how long remission lasted, another combination of three drugs from the first or second line may be used. If the disease is more aggressive, doctors may add a fourth drug or move to newer options faster.

SECOND-LINE THERAPY

When myeloma relapses for the first time

Combination of three drugs, often including drugs from the list above along with one or more of:

• Carfilzomib (Kyprolis)
• Ixazomib (Ninlaro)
• Elotuzumab (Empliciti)

The choice of drugs will depend on which drugs were used in the first-line therapy and how well they worked. Bone marrow transplant may also be an option.

FOURTH-LINE THERAPY

After the third relapse

Newer immunotherapies including:

• CAR T-cell therapy
• Bispecific antibodies
• Antibody-drug conjugate

Many of these target a protein in myeloma cells called BCMA.