3501 E3 CONNECT 4

Get four of the same color in a row by correctly answering Genetics questions!

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TEAM 1

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TEAM 2

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TEAM 3

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TEAM 4

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CONNECT 4

If Kool (XY) has hemophilia A, what could his mother's genotype be? Use the letter B for genotype.

Name the mutation. GCA > CCA

De'vante (XY) is heterozygous for albinism, homozygous dominant for Marfan syndrome, and homozygous recessive for congenital analgesia. What is his genotype? Use A for albinism, B for Marfan, and D for congenital analgesia.

What is the inheritance pattern of DMD?

Joe (32XY) has sickle cell anemia (SCA). His wife, Terri (33 XX) has the SCA trait. What is the probability of Joe and Terri having 2 of 5 children with just abnormal hemoglobin?

Color blindness is an X‑linked recessive trait in humans. A woman who is a carrier for color blindness has children with a man who is color blind. What is the likelihood that their first three children will be able to see color?

The equation to use for the following question: Betty (XX) and Von (XY) are both heterozygous for sickle cell anemia (SCA). What is the likelihood that their first three children will have SCA?

The inheritance pattern of Huntington disease

Name the mutation. TCT>GCT

How many mutated copies of the HTT gene does a male need to develop Huntington's disease?

Marvin has Fanconi anemia. His girlfriend, Tammy (XX), is a carrier. What is the likelihood they will have a child with Fanconi anemia?

Name the mutation. Original coding DNA sequence: 5’ …T A C A A A G T T C A G C G A G 3’ Mutated coding DNA sequence: 5’ …T A C A A A G A G T T C A G C 3’

Name three genes we have discussed.

Place a piece here if you can name a condition where Bb represents having the condition.

A circle with a dot in the middle could represent what condition?

Grady (XY) has X-SCID but was treated with gene therapy. He and his girlfriend, Faith (XX), want to know the likelihood that all four of their children will not have X-SCID. She is a carrier of the condition.

Name a condition that has an X-linked recessive inheritance pattern.

A single nucleotide change that causes no change in the protein sequence

Mutate the following sequence to cause a nonsense mutation. Coding sequence: 5’ G A C T C A C G T T A A C A T 3’

Trek (XY) - homozygous recessive for albinism and Huntington disease; heterozygous for CF Describe his phenotype for each condition.

The equation to use for the following question. Betty (XX) and Von (XY) are both heterozygous for sickle cell anemia (SCA). What is the likelihood that three of their six children will have SCA?

What do cystic fibrosis, albinism, and congenital analgesia have in common?

Give an example of a homozygous recessive genotype.

What are the chances that 3 out of 5 of their children will carry at least one mutated copy of the CFTR gene if both Selena (XX) and Tony (XXY) are heterozygous for cystic fibrosis (CF)?

B and b G and g These represent _____.

Translate the following sequence. Coding sequence: 5’ A C T A G A G G T C A T A 3’

If Parent A, who is homozygous dominant for eye color and wing length, is crossed with Parent B, who is heterozygous for eye color and wing length, what is the likelihood of them having offspring with the same phenotype as Parent B? Red eyes are dominant to white eyes; long wings are dominant to short wings.

Translate the following sequence. Coding sequence: 5’ G G A C T A G T C A G A C G T T A A C G A 3'

How many mutated copies of dystrophin, the gene associated with DMD, does a person need to develop DMD?

Africa(XX) is albino and is heterozygous for DMD and CF. Craig (XY) is heterozygous for CF, homozygous recessive for DMD, and has normal pigmentation. He does have a child with albinism. What are the chances they will have a child with albinism, DMD, and and is a carrier of the CF trait?

XAXa represents what phenotype for DMD?

Mutate the following sequence to cause a nonstop mutation. Coding sequence: 5’ G A C T C A T A A C A T 3’

Mutations occur in ___ in living organisms.

In a species of fly, smooth wings (W) are dominant to wrinkled wings, and red bodies (R) are dominant to yellow bodies. A WwRr and wwrr fly mate and produce the following offspring: Phenotype: Number of Offspring Smooth, red: 778 Smooth, yellow: 162 Wrinkled, red: 158 Wrinkled, yellow: 785 What is the percent recombination frequency for this cross?

Codon change that caused G356E.

Name an autosomal dominant condition.

AS represents what?

The only condition we have talked about that uses two different letters to represent genotype

Levi's (XY) genotype if he has albinismUse the letter B to represent albinism.

Lauren (XX) is a carrier of hemophilia. Her partner, Joe (XY), does not have hemophilia A. What is the probability that their first four children have the same phenotype as Lauren?

How many mutated copies of CFTR does a person need to develop CF?

Corey (XY) has DMD, while Belinda, his wife, is a carrier of the DMD trait. What is the likelihood that their first three children will be carriers of the DMD trait?