Mystery Mission:
The Mosquito Mystery
Start
Intro
The mosquito cases have been built, but something’s not adding up. Your job is to find the gaps in what’s known so far.
Continue
Mission 1: Unsolved Case
Locked
Locked
Locked
BRIEFING:
Date: November 1900Location: Camp Lazear, Cuba The mosquito experiments are underway, but the mystery of yellow fever isn’t solved yet. Dr. Reed needs your help to piece together the clues from three men who were infected: Dr. Jesse Lazear, Dr. James Carroll, and Private William Dean. Can you find what’s missing — and predict what Dr. Reed should do next?
Begin Mission 1
Submit for Review
Show the answers from your table to Mrs. K. to get the password.
Dr. Reed whispers the code to his helper
Mission 2: The Volunteer Dilemma
Locked
Completed
Locked
Mission Update:
Dr. Reed’s mosquito experiments may hold the key to solving the mystery of yellow fever — but they also come with great risk. New volunteers are needed. Before anyone steps forward, your team must carefully analyze both experiments and decide if the risk is worth the reward. Your task: reread the evidence, highlight key details, and chart the possible outcomes.
Begin Mission 2
Things were going well, but the team still had to face one enormously important problem: Where were the scientists going to find volunteers who were willing to take part in the new experimental tests? To present a watertight case, the team had to show that the mosquito hypothesis was true and that all the other old ideas about the cause of yellow fever were completely false. With the help of his colleagues, Reed had already proved that Bacillus icteroides didn’t cause the illness. Now the team needed to deal with the last two remaining theories. First, they had to prove once and for all that infected mosquitoes did cause yellow fever. And, second, they needed to show that being in contact with infected clothing and bedding was definitely ot the cause of the disease. To do that, they needed two sets of human volunteers for a series of experiments. The first set would have to spend several weeks wearing and using clothing and sheets that had been stained by the sweat, vomit, urine, and feces of yellow fever patients. The second set would have to do what Carroll, Dean, and Lazear had done. They would have to be bitten by infected mosquitoes. But how many normal, healthy, sensible people would volunteer for such disgusting and dangerous experiments? Of course, Reed could order soldiers to take part in the tests without telling them about the dangers or asking their permission. In 1900 scientists sometimes did something that is now illegal in the United States and many other countries. They sometimes dosed unsuspecting patients with disease germs or untested drugs without bothering to explain the risks or to ask these victims for consent. But Reed refused to do that. Like William Osier, the famous nineteenth-century doctor and professor of medicine, Walter Reed thought that “deliberately injecting a poison . . . into a human being, unless you obtain that man’s sanction [permission], is . . . criminal.”If Reed was going to do yellow fever experiments, he wanted to be honest and up-front about it. He wanted volunteers to know they were risking sickness and death by participating. What’s more, he wanted to do something new—something that scientists hadn’t done before. Because he felt his yellow fever insect experiments were extremely dangerous, Reed wanted each and every volunteer to sign a consent form indicating in writing that he or she was willing to undertake the experiment and truly understood the hazards. The question was, would Reed find anyone brave enough to sign up?
Mission 3: Consent Form
Completed
Completed
Locked
Mission Update:
Dr. Reed knows that his yellow fever experiments are risky, and he insists that every volunteer fully understands what they are signing up for. Before anyone can participate, you must step into the role of a researcher and unscramble the volunteer consent form.
Begin Mission 3
Completed
Completed
Completed
FINISH THE JOB
Mission Accomplished!
Congratulations, Researchers! You’ve helped uncover the truth about yellow fever and advanced Dr. Reed’s experiments. Your bravery and curiosity saved lives!
Correct!
Dean’s testimony helps prove the mosquito theory because he swears that he has not left the U.S. Army base in between the time that he was bitten by the mosquito and the time that he became ill.
Next
Well done, Researcher!
You’ve completed your first mission. Your next challenge: weigh the risks and rewards of becoming a volunteer.
Begin Mission 2
Correct!
Dean’s testimony helps prove the mosquito theory because he swears that he has not left the U.S. Army base in between the time that he was bitten by the mosquito and the time that he became ill.
Next
The Mosquito Mystery
Steph Kollbaum
Created on October 24, 2025
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Transcript
Mystery Mission:
The Mosquito Mystery
Start
Intro
The mosquito cases have been built, but something’s not adding up. Your job is to find the gaps in what’s known so far.
Continue
Mission 1: Unsolved Case
Locked
Locked
Locked
BRIEFING:
Date: November 1900Location: Camp Lazear, Cuba The mosquito experiments are underway, but the mystery of yellow fever isn’t solved yet. Dr. Reed needs your help to piece together the clues from three men who were infected: Dr. Jesse Lazear, Dr. James Carroll, and Private William Dean. Can you find what’s missing — and predict what Dr. Reed should do next?
Begin Mission 1
Submit for Review
Show the answers from your table to Mrs. K. to get the password.
Dr. Reed whispers the code to his helper
Mission 2: The Volunteer Dilemma
Locked
Completed
Locked
Mission Update:
Dr. Reed’s mosquito experiments may hold the key to solving the mystery of yellow fever — but they also come with great risk. New volunteers are needed. Before anyone steps forward, your team must carefully analyze both experiments and decide if the risk is worth the reward. Your task: reread the evidence, highlight key details, and chart the possible outcomes.
Begin Mission 2
Things were going well, but the team still had to face one enormously important problem: Where were the scientists going to find volunteers who were willing to take part in the new experimental tests? To present a watertight case, the team had to show that the mosquito hypothesis was true and that all the other old ideas about the cause of yellow fever were completely false. With the help of his colleagues, Reed had already proved that Bacillus icteroides didn’t cause the illness. Now the team needed to deal with the last two remaining theories. First, they had to prove once and for all that infected mosquitoes did cause yellow fever. And, second, they needed to show that being in contact with infected clothing and bedding was definitely ot the cause of the disease. To do that, they needed two sets of human volunteers for a series of experiments. The first set would have to spend several weeks wearing and using clothing and sheets that had been stained by the sweat, vomit, urine, and feces of yellow fever patients. The second set would have to do what Carroll, Dean, and Lazear had done. They would have to be bitten by infected mosquitoes. But how many normal, healthy, sensible people would volunteer for such disgusting and dangerous experiments? Of course, Reed could order soldiers to take part in the tests without telling them about the dangers or asking their permission. In 1900 scientists sometimes did something that is now illegal in the United States and many other countries. They sometimes dosed unsuspecting patients with disease germs or untested drugs without bothering to explain the risks or to ask these victims for consent. But Reed refused to do that. Like William Osier, the famous nineteenth-century doctor and professor of medicine, Walter Reed thought that “deliberately injecting a poison . . . into a human being, unless you obtain that man’s sanction [permission], is . . . criminal.”If Reed was going to do yellow fever experiments, he wanted to be honest and up-front about it. He wanted volunteers to know they were risking sickness and death by participating. What’s more, he wanted to do something new—something that scientists hadn’t done before. Because he felt his yellow fever insect experiments were extremely dangerous, Reed wanted each and every volunteer to sign a consent form indicating in writing that he or she was willing to undertake the experiment and truly understood the hazards. The question was, would Reed find anyone brave enough to sign up?
Mission 3: Consent Form
Completed
Completed
Locked
Mission Update:
Dr. Reed knows that his yellow fever experiments are risky, and he insists that every volunteer fully understands what they are signing up for. Before anyone can participate, you must step into the role of a researcher and unscramble the volunteer consent form.
Begin Mission 3
Completed
Completed
Completed
FINISH THE JOB
Mission Accomplished!
Congratulations, Researchers! You’ve helped uncover the truth about yellow fever and advanced Dr. Reed’s experiments. Your bravery and curiosity saved lives!
Correct!
Dean’s testimony helps prove the mosquito theory because he swears that he has not left the U.S. Army base in between the time that he was bitten by the mosquito and the time that he became ill.
Next
Well done, Researcher!
You’ve completed your first mission. Your next challenge: weigh the risks and rewards of becoming a volunteer.
Begin Mission 2
Correct!
Dean’s testimony helps prove the mosquito theory because he swears that he has not left the U.S. Army base in between the time that he was bitten by the mosquito and the time that he became ill.
Next