Cancer metabolism
Exploring metabolic vulnerabilities in cancer for therapeutic targeting and early detection
Marc HENNEQUART Group leader University of Namur Faculty of medicine Department of medicine Namur Research Institute for Life Sciences (NARILIS) Molecular Physiology Research Unit (URPhyM) Cancer metabolism lab
Cancer metabolism
About the PI
Expertise and research interests Holding a PhD in Biomedical sciences from the UCLouvain, Marc Hennequart is an experienced researchers in the field of cancer biology. His doctoral research, conducted at the Ludwig Institute for Cancer Research in Brussels, aimed at deciphering the pathways that lead to IDO1 constitutive expression in human cancer cells. After his PhD thesis, he pursued his academic career at The Francis Crick Institute in London. As a postdoctoral fellow, he explored the role of serine and one-carbon metabolism in cancer cell migration and metastasis, focusing on the mitochondrial enzyme ALDH1L2. In September 2023, Marc Hennequart joined the UNamur as Professor in Biochemistry and Cell biology for the bachelors in medicine and veterinary medicine. In parallel to his teaching activities, he established his own research group, in the continuity of his previous work. His team is investigating the metabolic pathways of amino acid degradation and their roles in cancer. Awards & Recognition Collen-Francqui Start-Up Grant 2023-2026
Marc HENNEQUART
Email
PubMed
ResearchGate
LinkedIn
Research Portal UNamur
Cancer metabolism
Research
Pancreatic cancer development
Harnessing the metabolic switch that occurs in early pancreatic cancer events for therapy and detection.
In collaboration with Dr. Abdenor Badaoui, CHU UCL Namur
Lung disease
Effect of indoor and outdoor volatile organic polutants on human lung disease
Mass spectrometry
Studying the metabolic contribution of tryptophan catabolism (IDO1/TDO2) in physiolical conditions of culture by Mass-spectrometry.
Cancer metabolism
Ongoing projects
Projects
Completed projects
Uncovering new metabolites for non-invasive pancreatic cancer detection. Télévie 2025
Harnessing the metabolic switch that occurs in early pancreatic cancer events for therapy and detection. Fondation contre le cancer 2024-2027
Cancer metabolism
Selected publications
Lee Y, Vousden KH, Hennequart M. Cycling back to folate metabolism in cancer. Nat Cancer. 2024 May;5(5):701-715.
Hennequart M, Pilley SE, Labuschagne CF, Coomes J, Mervant L, Driscoll PC, Legrave NM, Lee Y, Kreuzaler P, Macintyre B, Panina Y, Blagih J, Stevenson D, Strathdee D, Schneider-Luftman D, Grönroos E, Cheung EC, Yuneva M, Swanton C, Vousden KH. ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis. Cell Rep. 2023 May 26;42(6):112562.
Hennequart M, Labuschagne CF, Tajan M, Pilley SE, Cheung EC, Legrave NM, Driscoll PC, Vousden KH. The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells. Nat Commun. 2021 Oct 26;12(1):6176.
Hennequart M, Pilotte L, Cane S, Hoffmann D, Stroobant V, Plaen E, Van den Eynde BJ. Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance. Cancer Immunol Res. 2017 Aug;5(8):695-709.
Cancer metabolism
Team
Marc Hennequart
Isabelle Hamer
Charlotte Etienne
Hatice-Nur Özberk
Johanna Quintana
Group leader
Research scientist
Master student
Master student
PhD student
Virginie Tevel
Valérie Migeot
Research technician
Research technician
Marc Hennequart
Université de Namur
Created on August 18, 2025
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Transcript
Cancer metabolism
Exploring metabolic vulnerabilities in cancer for therapeutic targeting and early detection
Marc HENNEQUART Group leader University of Namur Faculty of medicine Department of medicine Namur Research Institute for Life Sciences (NARILIS) Molecular Physiology Research Unit (URPhyM) Cancer metabolism lab
Cancer metabolism
About the PI
Expertise and research interests Holding a PhD in Biomedical sciences from the UCLouvain, Marc Hennequart is an experienced researchers in the field of cancer biology. His doctoral research, conducted at the Ludwig Institute for Cancer Research in Brussels, aimed at deciphering the pathways that lead to IDO1 constitutive expression in human cancer cells. After his PhD thesis, he pursued his academic career at The Francis Crick Institute in London. As a postdoctoral fellow, he explored the role of serine and one-carbon metabolism in cancer cell migration and metastasis, focusing on the mitochondrial enzyme ALDH1L2. In September 2023, Marc Hennequart joined the UNamur as Professor in Biochemistry and Cell biology for the bachelors in medicine and veterinary medicine. In parallel to his teaching activities, he established his own research group, in the continuity of his previous work. His team is investigating the metabolic pathways of amino acid degradation and their roles in cancer. Awards & Recognition Collen-Francqui Start-Up Grant 2023-2026
Marc HENNEQUART
Email
PubMed
ResearchGate
LinkedIn
Research Portal UNamur
Cancer metabolism
Research
Pancreatic cancer development
Harnessing the metabolic switch that occurs in early pancreatic cancer events for therapy and detection.
In collaboration with Dr. Abdenor Badaoui, CHU UCL Namur
Lung disease
Effect of indoor and outdoor volatile organic polutants on human lung disease
Mass spectrometry
Studying the metabolic contribution of tryptophan catabolism (IDO1/TDO2) in physiolical conditions of culture by Mass-spectrometry.
Cancer metabolism
Ongoing projects
Projects
Completed projects
Uncovering new metabolites for non-invasive pancreatic cancer detection. Télévie 2025
Harnessing the metabolic switch that occurs in early pancreatic cancer events for therapy and detection. Fondation contre le cancer 2024-2027
Cancer metabolism
Selected publications
Lee Y, Vousden KH, Hennequart M. Cycling back to folate metabolism in cancer. Nat Cancer. 2024 May;5(5):701-715.
Hennequart M, Pilley SE, Labuschagne CF, Coomes J, Mervant L, Driscoll PC, Legrave NM, Lee Y, Kreuzaler P, Macintyre B, Panina Y, Blagih J, Stevenson D, Strathdee D, Schneider-Luftman D, Grönroos E, Cheung EC, Yuneva M, Swanton C, Vousden KH. ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis. Cell Rep. 2023 May 26;42(6):112562.
Hennequart M, Labuschagne CF, Tajan M, Pilley SE, Cheung EC, Legrave NM, Driscoll PC, Vousden KH. The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells. Nat Commun. 2021 Oct 26;12(1):6176.
Hennequart M, Pilotte L, Cane S, Hoffmann D, Stroobant V, Plaen E, Van den Eynde BJ. Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance. Cancer Immunol Res. 2017 Aug;5(8):695-709.
Cancer metabolism
Team
Marc Hennequart
Isabelle Hamer
Charlotte Etienne
Hatice-Nur Özberk
Johanna Quintana
Group leader
Research scientist
Master student
Master student
PhD student
Virginie Tevel
Valérie Migeot
Research technician
Research technician