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PUB_Is it normal aging or something more serious?

Deborah Kan

Created on April 29, 2025

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Transcript

The guide to

Is it normal aging or something more serious?

Brain aging

Early symptoms of cognitive decline

Protecting your brain

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The brain and aging

Occasional forgetfulness is part of getting older, but more serious memory problems could signal brain changes related to disease. So, what does "normal aging" look like?
A neurobiologist's perspective

In Alzheimer’s disease, we see tremendous changes in a part of the brain called the temporal lobe, where we see a lot of atrophy and a lot of shrinking. We also see this in the hippocampus, which is a structure in the brain that’s responsible for and involved in memory formation. So, there are patterns in the aging brain that can tell us a lot about the type of disease processes. This is something that we’ve been trying to leverage as we develop our approach to estimate brain age.

Dr. Andrei Irimia

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Biogerontologist, neurobiologist and assistant professor at USC

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Factors that can contribute to brain aging

Understanding the multiple factors that influence brain aging can help us take proactive steps to maintain cognitive health throughout our lives.

Exercise
Diet
Sleep
Stress
Socialization & loneliness
Alcohol & drug use

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Read more at beingpatient.com

Early signs of cognitive decline to look for

A doctor's perspective

"[There are] three main warning signs for primary care providers. These are: losing short-term memory, such as asking the same question repeatedly within a short time; having difficulty completing complex tasks, like following a recipe; and becoming disoriented in familiar places, such as getting lost on a route you’ve taken many times. If these signs are present, they should prompt a cognitive evaluation."

Dr. Barak Gaster

Cognition in Primary Care Director, University of Washington

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Possible root causes of cognitive symptoms

If your memory or other cognitive functions are impaired, a specialist might diagnose you with mild cognitive impairment, or MCI. Sometimes, this is caused by a disease like Alzheimer's or another form of dementia. But often, its root cause may be treatable—making these cognitive issues reversible. That's why it's so important to talk to a doctor if you're concerned.

Depression & anxiety

Metabolism & cardiovascular issues

Sleep deprivation

Chronic pain

Hormonal changes

Traumatic brain injury

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Read more at beingpatient.com

Should you get a baseline assessment?

A doctor's perspective

"[With] a gradually getting older person, where exactly do you establish that baseline? ... Your best baseline is actually your social network. So the person who knows you best is probably the most important person in terms of, 'Are you different than you were a year ago? Are there things that you could do a year ago that you can't do now.' You can do elaborate neuropsychological testing and none of it is as effective as just asking someone who really knows the person."

Dr. Bill Burke

WATCH THE FULL INTERVIEW

Geriatrician and psychiatrist

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Why are Black and Hispanic Americans at higher risk of developing cognitive decline?

Black Americans are

Hispanic Americans are

2x

1.5x

as likely to develop Alzheimer's than white Americans.

as likely as white Americans to develop Alzheimer's disease.

See the factors that experts believe contribute to the disproportionate dementia risk in Black Americans.

"Despite Higher Risk, Latin Americans Are Left Out of Alzheimer’s Studies. Here’s Why"

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READ MORE

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Hear about early signs from people living with cognitive decline: What’s normal, what’s not?

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Interactive quiz: What’s normal, what’s not?

Question 1/6

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Interactive quiz: What’s normal, what’s not?

Question 2/6

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Interactive quiz: What’s normal, what’s not?

Question 3/6

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Interactive quiz: What’s normal, what’s not?

Question 4/6

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Interactive quiz: What’s normal, what’s not?

Question 5/6

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Interactive quiz: What’s normal, what’s not?

Question 6/6

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Interactive quiz: What’s normal, what’s not?

NORMAL

1. You forgot where you put your keys but remember later.

NOT NORMAL

2. You forgot how to use your microwave after years of using it.

NORMAL

3. You occasionally forget a word but recall it later.

NOT NORMAL

4. You forget familliar names and struggle to recognize loved ones.

NORMAL

5. You forget an item on your to-do list.

NOT NORMAL

6. You get lost driving somewhere you've driven 100 times.

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Read more at beingpatient.com

How to spot and prevent memory loss

Neuroscientist and author Lisa Genova demystifies memory in her book Remember, offering clarity on normal forgetting versus dementia warning signs — plus science-backed strategies to strengthen memory.

A neuroscientist's perspective

"Our processing speeds slow as we age. That's normal. So we're always like, 'Oh, what's the name of that actor? What's the name of that show? What's the name of that city?' Normal. If you have Alzheimer's, you're going to have a hard time with regular common nouns, dozens of times a day... know that Alzheimer's is terrifying, but normal forgetting shouldn't be."

Lisa Genova

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Neuroscientist and author of Remember

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When to be concerned: Warning signs

Some memory problems go beyond normal aging. Here are key early signs:

Getting lost in familiar areas and difficulty driving.

Family expresses concern about your behavioral changes.

Frequent confusion with time or place.

Repeating the same questions over and over.

Changes in mood, personality, or judgment.

Difficulty following conversations.

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How to protect brain health

Even low-impact exercise like walking — boosts brain function.

Move your body

Learn a new language or musical instrument to increase neuroplasticity.

Flex your brain

A fiber- and omega-3 rich diet promotes gut and brain health.

Eat brain-healthy foods

Deep sleep clears harmful brain proteins, like the build up of tau.

Prioritize sleep

Prioritize social connection to reduce cognitive decline risk and loneliness.

Stay social

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Read more at beingpatient.com

What to do if you're concerned

If cognitive issues are affecting your day-to-day life, don’t wait.

  • Know your familial risk. Get up to speed on your family’s history with cognitive decline.
  • Keep a journal of your symptoms and concerns.
  • Talk to a doctor about cognitive testing.
  • Advocate for yourself. Continue to push for testing and care until you receive an accurate diagnosis.

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Want to keep learning?

Visit

beingpatient.com

for the latest news and information on brain health and Alzheimer's disease

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