Genetic diseases

What's inside? Why should you do it?

Genetic Disorders Word Games Magazine

Play the game!

We will show you information on a patient of a genetic disorder

Your objective is to memorize as much of the information as possible

We will then show you a table with information on many genetic disorders : you need to guess which one the patient has

What's the game?

What should I do?

But why?

THE RULES

Genetic Disorder Detective

ROUND 1

ARE YOU READY ?

🃏 Patient Card

• Age: 8 years old

• Symptoms: Frequent lung infections, difficulty breathing

• Family History: Two older siblings, one is also affected

• Additional Clue: High salt levels in sweat

• Type: Autosomal recessive

• Gene involved: CFTR gene

• Symptoms: Defective chloride channels causing mucus buildup

🃏 Mutation Card

🃏 Chromosome Card

Guess the answer !

• Affected chromosome: Chromosome 7

• Mutation location: ΔF508 deletion

• Caused by a mutation in the CFTR gene

• Autosomal recessive disorder

• Leads to thick mucus buildup in the lungs and digestive system

• Treated with physiotherapy, medications, and lung transplants in severe cases

🏥 Correct ! Cystic Fibrosis

Try again...

ROUND 2

ARE YOU READY ?

🃏 Patient Card

• Age: 6 years old

• Symptoms: Episodes of severe pain, fatigue, swollen hands and feet

• Family History: Both parents are carriers, one sibling is also affected

• Additional Clue: Low red blood cell count (anemia)

• Type: Autosomal recessive

• Gene involved: HBB gene

• Symptoms: Abnormal hemoglobin causing red blood cells to become sickle-shaped, leading to blockages in blood vessels, pain crises, and anemia

🃏 Mutation Card

🃏 Chromosome Card

Guess the answer !

• Affected chromosome: Chromosome 11

• Mutation location: Single nucleotide mutation (Glu6Val) in the β-globin gene

Try again...

• Caused by a mutation in the HBB gene

• Autosomal recessive disorder

• Leads to sickle-shaped red blood cells, causing blockages, pain crises, and anemia

• Treated with pain management, blood transfusions, and bone marrow transplants in severe cases

🏥 Correct !Sickle Cell Anemia

Don't forget to do all the games in our magazine ; we will provide you with the answers after the holidays

Thank you for playing!