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Angelica Benitez
Created on November 19, 2024
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Transcript
What is the estradiol concentration compared to baseline of 4mcg?
4.3 vs 3.9 pg/ml
no change
15 vs 8 pg/ml
What are the indications
Treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause
Treatment of moderate to severe dyspaerunia due to posmenopause
Treatment of severe dyspareunia
What drug class and MOA
Circulating estrogens modulate the pituitary secretion of the gonadotropins, luteinizing hormone (LH), and FSH, through a negative feedback mechanism
The insert comes in contact with the vaginal mucosa, estradiol is released into the vagina.
Estrogens act to reduce the elevated levels of LH hormones seen in postmenopausal women
How is IMVEXXY administered
1 vaginal insert daily for 2 weeks, followed by 1 insert twice weekly.
1 vaginal insert daily for 1 weeks.
1 vaginal insert daily for 2 weeks
How is product stored
Store at 20°C to 25ºC (68°F to 77ºF)
Store at 28°C to 30ºC
Store at 72°F to 86ºF
NO BOX WARNING.
Which one of these are included in boxed warning?
ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, PROBABLE DEMENTIA
HEADACHE, DEMENTIA,NAUSEA
The most common adverse reaction with IMVEXXY (incidence ≥ 3% and greater than placebo)
CARDIOVASCULAR EVENTS
VAGINAL DISCHARGE
HEADACHE
Which dose has an LS change from baseline as -1.52
4mcg
1mg
10mcg
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If you want to provide additional information or develop the content in more detail, you can do so through your oral presentation. We recommend that you practice your voice and rehearse: the best improvisation is always the most prepared!
Share your idea with an image
If you want to provide additional information or develop the content in more detail, you can do so through your oral presentation. We recommend that you practice your voice and rehearse: the best improvisation is always the most prepared!
Share your idea with an image
If you want to provide additional information or develop the content in more detail, you can do so through your oral presentation. We recommend that you practice your voice and rehearse: the best improvisation is always the most prepared!
Share your idea with an image
If you want to provide additional information or develop the content in more detail, you can do so through your oral presentation. We recommend that you practice your voice and rehearse: the best improvisation is always the most prepared!
Share your idea with an image
If you want to provide additional information or develop the content in more detail, you can do so through your oral presentation. We recommend that you practice your voice and rehearse: the best improvisation is always the most prepared!
Share your idea with an image
If you want to provide additional information or develop the content in more detail, you can do so through your oral presentation. We recommend that you practice your voice and rehearse: the best improvisation is always the most prepared!
Share your idea with an image
If you want to provide additional information or develop the content in more detail, you can do so through your oral presentation. We recommend that you practice your voice and rehearse: the best improvisation is always the most prepared!