HEALTH SCIENCES PRESENTATION

Hydroxyurea

• Increases fetal Hgb

Prophylactic Penicillin

• Protects against encapsulated organisms up to age 5

Immunizations

• Pneumococcal, meningococcal, HiB and routine vaccinations

RBC Transfusion

• Indicated when hemoglobin below baseline with clinical decline

Hematopoitic Stem Cell Transplant

• Curative measure

LONG-TERM MANAGEMENT

Hypertension secondary to reduced flow/micro-infarctsRenal papillary necrosis Labs: Renal Function Panel Imaging: RBUS w/doppler Management: - Anti-hypertensives (valsartan shown to decrease stickiness of RBCs)

Chronic Complications

• Poor growth
• Renal Disease
• Osteonecrosis
• Functional Asplenia
• Cholelithiasis

SOB, tachypnea, chest pain, leg pain swelling Imaging: US, CXR, CTPA Management: - Anticoagulation (heparin, warfarin) - D-dimer not accurate due to over-activation of coagulation cascade at baseline.

New infiltrate on CXR + fever/respiratory symptomsLabs: CBCD + Rtc Management: - Optimize ventilation - Hydration and pain control - Antibiotics: 3rd generation cephalosporin + macrolide - Blood transfusion as needed

Acute Complications

• Vaso-occlusive Crisis
• Acute Chest Syndrome
• Splenic Sequestration
• DVT/PE
• Stroke
• Sepsis
• Dactylitis
• Priapism

RENAL DISEASE

DVT/PE

ACUTE CHEST SYNDROME

Sickle Cell Disease Complications