LISTA QUÍMICA

The role of biotechnology in insuline

Sergio Malagón Molina

2.º Productos Farmaceuticos

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INDEX

INTRODUCTION

INSULIN ADMINISTRATION

INSULIN

CONCLUSION

BIOTECHNOLOGICAL REVOLUTION

BIBIOGRAPHY

INTRODUCTION

TYPE OF DIABETES

HISTORYOF INSULIN

INSULIN

INSULIN IS A HORMONE THAT IS PRODUCED BY THE PANCREAS. IT HELPS MOVE BLOOD GLUCOSE (BLOOD SUGAR) FROM YOUR BLOODSTREAM INTO YOUR CELLS, WHERE IT IS USED FOR ENERGY. GLUCOSE CAN BE OBTAINED FROM MANY FOODS YOU EAT. IT IS YOUR BODY´S MAIN SOURCE OF ENERGY.

BIOTECHNOLOGICAL REVOLUTION

BIOTECH

INSULIN ADMINISTRATION

INVASIVE METHOD

NON-INVASIVE METHODS

ADMINISTRATION DEVICES

CONCLUSION

The discovery of insulin and its evolution, especially with the production of recombinant insulin, has been fundamental in the treatment of diabetes. These advances have made it possible to have more efficient and accessible for patients to. The development of devices such as insulin pens and pumps has transformed the administration of treatment, making it more precise, comfortable and personalized. Thanks to these technological advances, patients can manage their glucose levels better, improving their quality of life. In short, biotechnology has played a crucial role in the evolution of diabetes treatment, offering more effective solutions tailored to individual needs.

BIBLIOGRAPHY

1. MedlinePlus. (n.d.). Insulin in blood. U.S. National Library of Medicine. https://medlineplus.gov/lab-tests/insulin-in-blood/ 2. MedlinePlus. (n.d.). Diabetes. U.S. National Library of Medicine. https://medlineplus.gov/diabetes.html 3. Korion LS. (2023). Diabetes: Disrupting the most prevalent metabolic disease. Korion LS. https://korionls.com/en/diabetes-disrupting-the-most-prevalent-metabolic-disease/ 4. Revista Diabetes. (2023). Avances en los métodos de administración de insulina. Revista Diabetes. https://www.revistadiabetes.org/tratamiento/avances-en-los-metodos-de-administracion-de-insulina/ 5. Roche Plus. (n.d.). Parche all-in-one. Roche. https://www.rocheplus.es/innovacion/tecnologia/parches-all-in-one.html#:~:text=Su%20funcionamiento%20es%20muy%20simple,cesa%20el%20suministro%20de%20insulina.

BIBLIOGRAPHY

6. Cleveland Clinic. (2023). Insulin pumps. Cleveland Clinic. https://my.clevelandclinic.org/health/articles/insulin-pumps 7. Heinemann, L., & Schmid, C. (2013). Insulin pumps and continuous glucose monitoring: Challenges and opportunities. National Library of Medicine. https://pmc.ncbi.nlm.nih.gov/articles/PMC3714061/ 8.National Library of Medicine. (n.d.). Recombinant DNA technology: An alternative to animal insulin. U.S. National Library of Medicine. https://www.nlm.nih.gov/exhibition/fromdnatobeer/exhibition-interactive/recombinant-DNA/recombinant-dna-technology-alternative.html Diabetes UK. (n.d.). 9.Types of diabetes. Diabetes UK. https://www.diabetes.org.uk/about-diabetes/types-of-diabetes 10.University of California, San Francisco. (n.d.). Treatment of type 2 diabetes: Insulin administration. UCSF Diabetes Care. https://dtc.ucsf.edu/types-of-diabetes/type2/treatment-of-type-2-diabetes/medications-and-therapies/type-2-insulin-rx/insulin-administration/

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ADHESIVE PATCH

The adhesive patch analyzes the blood sugar level and has a sufficient amount of insulin to be administered to the patient, using small needles at the moment when the levels vary.

HISTORY OF INSULIN

Insulin was discoverd in 1921 by Frederick Banting and Charles Best, mainly from pork pancreas insulin. For years, this animal insulin was used to diabetes in humans.

However, as animal insulin is not identical to human insulin, it caused problems with some patients.

PRODUCTION OF RECOMBINANT INSULINE

The recombinant insulin production involves inserting gene encoding human insulin into a vector. it`s later introduced in the bacteria. These cells produce insuline naturally, which is then purified for medical use.

• ADVANTAGES:

The advantages of recombinant insuline are numerous --> It has an identical composition to human insulin, reducing the risk of rejection. -It allows a high level of production, ensuring a constant and accessible supply.

INSULIN INHALER

These are devices that convert insulin powder in to inhalable particles. Patients inhale the insulin, which is then absorbed through the lung alveoli into the bloodstream.

• ADVANTAGES

Non-invasive:Eliminates the need for needles and reducing pain.

• DISADVANTAGES

Inhalation of insulin can decrease lung function and cause bronchospasms.

INSULIN PEN

Insuline pens are devices that contain insulin cartridges. Their design allows patients to inject insulin accurately

FEATURES

• Adjustable dosage: they allow the administration of exact doses, facilitating customization.
• Precision: The injection is more precise compared to traditional syringes, reducing the risk of dosing errors.

INSULIN PUMPS

Insulin pumps are electronic devices that administer insulin continuously through a catheter placed under the skin.

FEATURES

• Continuous Administration: They provide constant insulin, which help maintain stable glucose levels throughout the day.
• Dose control
• Custom programming