Copy of 2.2.4 Clues in the Chromosomes.pptx

2.2.4 Clues in the Chromosomes

A NOT-SO-WELL VISIT

MEET YOUR NEXT PATIENT! RILEY HERNANDEZ

5 year old female In the clinic with her father, Julio

RELEVANT HISTORY

Concerns about short height

• previously discussed nutrition recommendations with family
• Height goal: 94 cm

DID SHE REACH HER HEIGHT GOAL?

Growth Concerns

You have serious concerns about Riley not meeting her height goals. You must consider a variety of possible causes. Brainstorm with a partner to generate a list of ideas about what could be causing this delay in growth for Riley. When finished, share your list with the class and discuss.

STEPS TOWARDS DIAGNOSIS

POSSIBLE HORMONE IMBALANCE?

WHAT ARE HORMONES?

WHAT SECRETES HORMONES?

WHAT SYSTEM CONTROLS HORMONES?

EXAMPLES OF HORMONES THAT REGULATE GROWTH

RILEY'S RESULTS:

CHROMOSOMAL DISORDERS

What are chromosomes? What is a chromosomal disorder? How is that different from a single gene disorder?

IT'S YOUR TURN!

READ THE HISTORICAL HIGHLIGHT

WHAT IS A CHROMOSOME SPREAD?

Watch the Chromosome spread module videos together 2.2.4 > chromosome spreads

• what is a cytogeneticist?
• what was Barbara McClintock's contribution to genetics?
• what is a "jumping gene" (transposable element)?

TO THE LAB!

YOU WILL USE HUMAN TUMOR CELLS TO CREATE A CHROMOSOME SPREAD THEN YOU WILL STAIN THE CHROMOSOMES THEN, VIEW UNDER A MICROSCOPE

ETHICS DISCUSSION:

• TREATING HUMAN CELLS WITH RESPECT
• HENRIETTA LACKS & THE CONTRIBUTION OF HELA CELLS

KARYOTYPING

How many chromosomes does a typical human somatic cell have? How many pairs? How many are autosomes? How many are sex chromosomes?

Is this individual male or female?