2.2.1+Bothersome+Bumps.pptx.pptx

2.2.1 Bothersome Bumps

PBS

Meet Kai Rossi!

• 7 year old 
• Male
• Unexplained bumps under skin on legs
• Ordered an MRI 

It's Your Turn! Preliminary Possibilities

Go to PLTW 2.2.1 > Cellular Concerns

• Terminology - define differential diagnosis & answer reflection question (under Preliminary Possibilities)

• Step 1 – review Kai's patient portal
• Record MRI results and any other concerning info

• Step 2 – work with a partner to research to generate a differential diagnosis (create a list of at least 3 possibilities).

Behind the Biopsy

To understand what is causing the solid mass tumors, we must have a full understanding of human cells

• Humans are made of _______________ cells (have a nucleus + organelles).
• There are about 200 different cell types in the human body, but they can be categorized into 2 major groups:

Somatic Cells Germ Cells

Eukaryotic

Behind the Biopsy

Regardless of type, all cells must reproduce (make copies of themselves)

• Why?

• How?

growth, replacing old or damaged cells

mitosis (division of nucleus) & cytokinesis (division of cellular contents)

Before mitosis...

• Chromosomes must ________________

• What is a chromosome?

Replicate

DNA wrapped around histone proteins (to prevents tangling). Contains genetic information in the form of genes. Humans have 46 chromosomes (23 pairs)

It's Your Turn!  Mitosis

• In Schoology, open the Mitosis Assignment (2.2.1 folder)
• Review the attached Mitosis powerpoint and complete the handout.
• Fill in the blank
• Answer questions
• Draw the following in all stages of division:
• chromosomes
• centrioles
• spindle

Tumor formation

• Caused by ________________________________________

uncontrolled cell division

It's Your Turn!

Go to PLTW 2.1.5 > Division Gone Wrong

• Review the terms in the "Terminology - Tumors" table and take notes if needed
• Step 4 – write a paragraph with the terms

• Review the Biodigital interactive under "Types of Tissue"
• Complete the "Check for Understanding" at the bottom of this section

It's Your Turn!

• Examine Kai's biopsy and cytopathologist notes (2.1.5>Cellular Survey Says -> read note under the photo)

• Step 9 – revisit your differential diagnosis and discuss with your partner/group - make an official diagnosis
• Share your diagnosis with me
• Step 11 – research Kai's condition - use the NIH website
• What is the cause?
• Is it cancer?
• Is it inherited? Spontaneous?
• What are the major signs and symptoms?
• Potential severe complications?
• Treatments?