Final Draft- Tissue Engineering

MACROPHAGE

Tendon Restoration In Fibrous Connective Tissue

To restore tendons in fibrous connective tissue, we rely on macrophage cells. Macrophage cells go through a process where they first clear away debris and dead cells from the injured area through phagocytosis. Next, they transition to the next state where secrete growth factors help produce collagen. Once both of these processes are done, the tissue will start to regenerate and will remodel while the wound heals.

Tenoblasts

Tenoblasts cells deposit collagen fibers during the healing phase and transform into tenocytes in the last repair phase. It is suggested that tenoblasts are dominant in young tendons and that they transform into tenocytes during maturation and aging. Tenoblasts represent approximately 90% to 95% of tendon fibroblasts. These specialized fibroblasts produce extracellular matrix components, including collagen and proteoglycans.

TENOCYTES

Tenocyte is the primary cell type in tendons and is responsible for maintaining the tendon's ECM. It produces the growth factors and type 1 collage that assists with the remodeling. This process will help lead and prolong the healing during injury and repair.

Producing tendon fibrous tissue involves sourcing cells, culturing them on scaffoulds, and using the formed tissue for therapeutic repair.