Reprogramming the Pancreas

Step 2

Step 1

To create a new pancreas using beta, alpha, and endocrine cells, scientists first isolate stem cells capable of differentiating into these specialized pancreatic cells. Through precise gene editing or chemical signaling, these stem cells are programmed to become beta cells (which produce insulin), alpha cells (which secrete glucagon), and other endocrine cells responsible for producing hormones like somatostatin and pancreatic polypeptide. These cells are then combined in a scaffold or 3D bioprinted matrix mimicking the natural pancreatic structure, allowing them to organize and function as a cohesive unit. The bioengineered pancreas must undergo testing to ensure it can regulate blood sugar effectively. Once functional, it is implanted into the patient, integrating with blood vessels and nerves, restoring pancreatic function.

How the Two Combine(Our Process)

The Issue at Hand

Beta cells eng.

Cells Utilized in Our Treatment

In pancreatic cancer, normal pancreas cells undergo genetic mutations, leading to uncontrolled growth and the formation of a tumor. These cancerous cells evade cell death, invade surrounding tissues, and may spread (metastasize) to other organs. This disrupts the pancreas's normal functions, including enzyme production and blood sugar regulation.

Rebuilding the Pancreas

Samantha Jimenez, Lyla Youkhana, Naomi Inthirath

Generating Beta Cells

- All these cell types share early development stage with beta cells and so can be used to create them by activating insulin producing cells. Hepatocytes Ductal cells a cells Acinar cells B cells - regeneration