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Reasons For Knee cartillage replacement

• osteoarthritis
• wore down cartillage
• rheumatoid arthritis:
• inflamation in the joints causing cartillage breakdown
• Injury
• Avascular Necrosis
• This condition occurs when the blood supply to the bone
• Tears in the meniscus

Knee Cartillage replacement

how the cells are harvested

ways the 3D systems are implemented

• After formed into a 3D system they are placed into the damaged part of the knee through any of these techniques:

• Microfracture: Small holes are drilled into the bone beneath the damaged cartilage to stimulate the growth of new cartilage
• Autologous Chondrocyte Implantation (ACI): Cultured chondrocytes are injected into the defect and covered with a membrane to keep them in place.
• Matrix-induced autologous Chondrocyte Implantation (MACI): Chondrocytes are seeded onto a scaffold before being implanted.

• Chondrocytes
• harvested from the patient’s cartilage (autologous) or donor tissue (allogeneic)
• MSCs
• sourced from bone marrow or adipose tissue
• (iPSCs):
• derived from the patient’s own cells.

How Cells are combined to create cartilage

To create functional cartilage, chondrocytes, MSCs, and iPSC-derived chondrocytes are often combined in 3D culture systems or scaffolds. 3D scaffolds are 3D structures made from biocompatible materials that provide a framework for new cartilage to grow they are designed to degrade over time as new tissue forms.

recovery

• Recovery includes physical therapy which is the crucial part to restore joint function and strength.