Halloween escape-antibiotic pk/pd

Antibiotics pharmacokinetics/pharmacodynamics

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Get all the candy!

escape halloween

ANSWER THE FOLLOWING QUESTIONS TO GET CANDIES. 🎃👻🍬

go!

Go house to house!

🔒

🔒

🔒

🔒

Candy obtained

Witch's house

ANSWER THE WITCH'S QUESTION ABOUT VANCOMYCIN TO UNLOCK THE DOOR.

knock

1/3

vANCOMYCIN IS MAINLY ELIMINATED BY_____?

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knock

Hepatic metabolism

Biliary excretion

Glomerular filtration

2/3

AN APPROPRIATE AUC24H/MIC FOR TREATING MRSA INFECTIONS IS_____.

200

450

650

3/3

WHAT SHOULD YOU MEASURE TO MONITOR VANCOMYCIN?

Serum concentration

Urine concentration

Saliva concentration

Spooktacular!

You've passed the first test and scored some candy. Keep it up!

continue

Candy obtained

Go to the next house!

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✔️

Candy obtained

House of the Wolf

In the house of the wolf you have to answer questions about aminoglycosides.

knock

1/4

Aminoglycosides are mainly eliminated by which route?

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knock

Hepatic

Exhalation

Renal

2/4

Aminoglycosides can be administered by which of the following routes?

Intramuscular

Oral

Subcutaneous

3/4

The PK/PD parameter that correlates with the efficacy of aminoglycosides is______.

fCmin/MIC

fAUC/MiC

fCmax/MiC

4/4

What is the dose of tobramycin in mg for a 57 yom who weights 220 lb and measures 5'9'' if the initial dose is 5 mg/kgx1?

354

412

500

Awesome!

You've outsmarted the wolf, and your candy bag grows.

continue

Candy obtained

Go to the next house!

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🔒

✔️

✔️

Candy obtained

Frankenstein's House

You have to do some calculations in this house. ⚡

knock

1/3

DC is a 20 yom (71’’, 192 lb, SCr 1) male for whom vancomycin was ordered. What loading dose will be appropriate?

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knock

3250 mg

1250 mg

2000 mg

2/3

DC received the dose you recommened over 2 hrs. Vancomycin concentrations were 29.5 mg/l and 10.3 mg/l 2 hrs and 10 hrs after completion of dose, respectively. What is the half-life of vancomycin?

6.5 hr

5.3 hr

7.2 hr

3/3

Calculate DC's volume of distribution based on the dose and the measured concentrations?

34.9 L

52.1 L

61.1 L

You rock!

You've unraveled the mysteries of Frankenstein and scored more candy.

continue

Candy obtained

Go to the next house!

🔒

✔️

✔️

✔️

Candy obtained

House of the Mummy

You'll do more calculations in this house!

knock

1/4

Calculate the clearance of vancomycin in DC?

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knock

4.1 L/hr

5.1 L/hr

6.9 L/hr

2/4

What dose given in 24 hours will provide an AUC of 500?

2060 mg

3450 mg

4100 mg

3/4

What is the appropriate maintainance dose of vancomycin for DC?

500 mg Q8H

1000 mg Q6h

1750 mg Q12h

4/4

If you canged the patient's dose to a continuous infusion using the same total daily dose, what will be the steady state concentraiton?

21.1

10.6

42.2

Fantastic!

You've unraveled the mummy's secrets and bagged more candy.

continue

Candy obtained

There is only one house left!

✔️

✔️

✔️

✔️

Candy obtained

Dracula's house

In this house you will dose vancomycin for a patient on hemodialysis?

knock

1/3

ZE is a 72 year old female (65'', 172 lb, SCr 9.1 mg/dL) with ESRD on HD three times a week. What intial dose of vancomycin will be appropriate for ZE?

knock

knock

1000 mg q12h

1750 mg x1

2750 mg x1

1250 mg Q24h

2/3

ZE received the dose you recommended. Serum concentration measured 24 hours later (before dialysis was 25 mg/L. What subsequent dose should ZE receive?

750 mg x1

1000 mgx1

1250 mgx1

None

3/3

If warranted, ZE should receive vancomycin_________.

Before dialysis

During dialysis

After dialysis

You're a legend!

You've bested the one and only Dracula, and your candy bag is bursting.

continue

Candy obtained

You did it!

Your journey has been fang-tastically amazing, and your candy haul is out of this world!

Are you sure you want to go out?

If you exit you will return to the start of the game and you will lose your progress

back

exit

Oh! You have failed...

try again!