Halloween escape-antibiotic pk/pd

Antibiotics pharmacokinetics/pharmacodynamics

Get all the candy!

start

escape halloween

ANSWER THE FOLLOWING QUESTIONS TO GET CANDIES. 🎃👻🍬

go!

Go house to house!

Candy obtained

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Witch's house

ANSWER THE WITCH'S QUESTION ABOUT VANCOMYCIN TO UNLOCK THE DOOR.

knock

Biliary excretion

1/3

vANCOMYCIN IS MAINLY ELIMINATED BY_____?

Hepatic metabolism

Glomerular filtration

knock

knock

650

2/3

AN APPROPRIATE AUC24H/MIC FOR TREATING MRSA INFECTIONS IS_____.

450

200

Saliva concentration

3/3

WHAT SHOULD YOU MEASURE TO MONITOR VANCOMYCIN?

Serum concentration

Urine concentration

Spooktacular!

You've passed the first test and scored some candy. Keep it up!

Candy obtained

continue

Go to the next house!

Candy obtained

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✔️

House of the Wolf

In the house of the wolf you have to answer questions about aminoglycosides.

knock

1/4

Aminoglycosides are mainly eliminated by which route?

Hepatic

Exhalation

Renal

knock

knock

2/4

Aminoglycosides can be administered by which of the following routes?

Intramuscular

Oral

Subcutaneous

3/4

The PK/PD parameter that correlates with the efficacy of aminoglycosides is______.

fCmin/MIC

fAUC/MiC

fCmax/MiC

4/4

What is the dose of tobramycin in mg for a 57 yom who weights 220 lb and measures 5'9'' if the initial dose is 5 mg/kgx1?

500

354

412

Awesome!

You've outsmarted the wolf, and your candy bag grows.

Candy obtained

continue

Go to the next house!

Candy obtained

✔️

🔒

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Frankenstein's House

You have to do some calculations in this house. ⚡

knock

1/3

DC is a 20 yom (71’’, 192 lb, SCr 1) male for whom vancomycin was ordered. What loading dose will be appropriate?

3250 mg

1250 mg

2000 mg

knock

knock

2/3

DC received the dose you recommened over 2 hrs. Vancomycin concentrations were 29.5 mg/l and 10.3 mg/l 2 hrs and 10 hrs after completion of dose, respectively. What is the half-life of vancomycin?

6.5 hr

5.3 hr

7.2 hr

3/3

Calculate DC's volume of distribution based on the dose and the measured concentrations?

34.9 L

52.1 L

61.1 L

You rock!

You've unraveled the mysteries of Frankenstein and scored more candy.

Candy obtained

continue

Go to the next house!

Candy obtained

✔️

✔️

🔒

✔️

House of the Mummy

You'll do more calculations in this house!

knock

1/4

Calculate the clearance of vancomycin in DC?

4.1 L/hr

5.1 L/hr

6.9 L/hr

knock

knock

2/4

What dose given in 24 hours will provide an AUC of 500?

2060 mg

3450 mg

4100 mg

3/4

What is the appropriate maintainance dose of vancomycin for DC?

1750 mg Q12h

500 mg Q8H

1000 mg Q6h

4/4

If you canged the patient's dose to a continuous infusion using the same total daily dose, what will be the steady state concentraiton?

21.1

10.6

42.2

Fantastic!

You've unraveled the mummy's secrets and bagged more candy.

Candy obtained

continue

There is only one house left!

Candy obtained

✔️

✔️

✔️

✔️

Dracula's house

In this house you will dose vancomycin for a patient on hemodialysis?

knock

1/3

ZE is a 72 year old female (65'', 172 lb, SCr 9.1 mg/dL) with ESRD on HD three times a week. What intial dose of vancomycin will be appropriate for ZE?

1000 mg q12h

1750 mg x1

2750 mg x1

1250 mg Q24h

knock

knock

2/3

ZE received the dose you recommended. Serum concentration measured 24 hours later (before dialysis was 25 mg/L. What subsequent dose should ZE receive?

750 mg x1

1000 mgx1

1250 mgx1

None

3/3

If warranted, ZE should receive vancomycin_________.

Before dialysis

During dialysis

After dialysis

You're a legend!

You've bested the one and only Dracula, and your candy bag is bursting.

Candy obtained

continue

You did it!

Your journey has been fang-tastically amazing, and your candy haul is out of this world!

Are you sure you want to go out?

If you exit you will return to the start of the game and you will lose your progress

back

exit

Oh! You have failed...

try again!