Escape of the Bone Zone
Iren Gharibyan
Created on September 5, 2024
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Transcript
Escape of the...
Iren Gharibyan
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BONE ZONE
Intro
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You find yourself in the shadowy streets of a dark, deserted city. The air is thick with mystery, and malignant forces lurk around every corner. To escape, you must navigate through a series of bone-chilling challenges, cracking the code of malignant bone tumors before the city swallows you whole. Time is running out—can you escape this skeletal maze before it’s too late?
Mission 1
Locked
Locked
Locked
Ewing Sarcoma
Giant Cell Tumor
What is the most common primary bone tumor in young adults, often presenting as a painful, enlarging mass?
Osteosarcoma
Mission 2
Completed
Locked
Locked
Drag and discover
Chondrosarcoma
Wronganswer
Osteosarcoma
Which of the following tumors is associated with the Codman triangle and sunburst pattern on X-ray?
Ewing Sarcoma
Mission 3
Completed
Completed
Locked
Osteochondroma
Ewing Sarcoma
Which tumor is found in the diaphysis of long bones and commonly affects the femur?
Osteosarcoma
Wnt/β-catenin pathway
Hedgehog signaling pathway
RANK/RANK-L pathway
Which molecular pathway is highly active in Giant Cell Tumor of the bone?
Giant Cell Tumor
Osteosarcoma
Ewing Sarcoma
This bone tumor is caused by the fusion of EWSR1 and FLI1 genes. What is it?
216
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Remember the code
Completed
Mission 4
Completed
Completed
Diaphysis
Epiphysis
Metaphysis
Giant Cell Tumor of the bone primarily affects which part of the bone and is known for its locally aggressive behavior?
Immediate radiation therapy
Surgical excision followed by antibiotic therapy and monitoring
Neoadjuvant chemotherapy followed by limb-sparing surgery
A 16-year-old male presents to the clinic with a 3-month history of progressively worsening pain in his right knee. He describes the pain as constant, dull, and worse at night. On physical exam, there is localized swelling over the distal femur, and tenderness to palpation. An X-ray of the knee reveals a destructive lesion in the metaphysis of the distal femur, with evidence of periosteal elevation forming a Codman triangle and a sunburst pattern. Biopsy of the lesion shows pleomorphic cells producing an irregular osteoid matrix.
14+3
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Completed
Completada
Completada
Completed
Completed
Completada
Completed
Completada
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