Escape of the Bone Zone

Escape of the...

Iren Gharibyan

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BONE ZONE

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You find yourself in the shadowy streets of a dark, deserted city. The air is thick with mystery, and malignant forces lurk around every corner. To escape, you must navigate through a series of bone-chilling challenges, cracking the code of malignant bone tumors before the city swallows you whole. Time is running out—can you escape this skeletal maze before it’s too late?

Mission 1

Locked

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Ewing Sarcoma

Giant Cell Tumor

What is the most common primary bone tumor in young adults, often presenting as a painful, enlarging mass?

Osteosarcoma

Mission 2

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Locked

Drag and discover

Chondrosarcoma

Wronganswer

Osteosarcoma

Which of the following tumors is associated with the Codman triangle and sunburst pattern on X-ray?

Ewing Sarcoma

Mission 3

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Completed

Locked

Osteochondroma

Ewing Sarcoma

Which tumor is found in the diaphysis of long bones and commonly affects the femur?

Osteosarcoma

Wnt/β-catenin pathway

Hedgehog signaling pathway

RANK/RANK-L pathway

Which molecular pathway is highly active in Giant Cell Tumor of the bone?

Giant Cell Tumor

Osteosarcoma

Ewing Sarcoma

This bone tumor is caused by the fusion of EWSR1 and FLI1 genes. What is it?

216

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Remember the code

Completed

Mission 4

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Completed

Diaphysis

Epiphysis

Metaphysis

Giant Cell Tumor of the bone primarily affects which part of the bone and is known for its locally aggressive behavior?

Immediate radiation therapy

Surgical excision followed by antibiotic therapy and monitoring

Neoadjuvant chemotherapy followed by limb-sparing surgery

A 16-year-old male presents to the clinic with a 3-month history of progressively worsening pain in his right knee. He describes the pain as constant, dull, and worse at night. On physical exam, there is localized swelling over the distal femur, and tenderness to palpation. An X-ray of the knee reveals a destructive lesion in the metaphysis of the distal femur, with evidence of periosteal elevation forming a Codman triangle and a sunburst pattern. Biopsy of the lesion shows pleomorphic cells producing an irregular osteoid matrix.

14+3

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