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Hemocianina

Diva Manuel

Created on May 16, 2024

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Transcript

Hemocianina

Será que podemos utilizar as características da hemocianina para solucionar problemas na ciência?

go!

Disponível em: Imagem- PBD 1JS8

PL1, Grupo 1- Ana Torres e Diva Manuel

Hemocianina

+O2

Deoxy-Hemocianina Cu(I) geometria trigonal piramidal Cu(I) d10 Incolor

Oxi-Hemocianina Cu(II) geometria tetraédrica distorcida Cu(II) d9 Cor azul

Disponível em: https://www.google.com/imgres?q=hemocyanin&imgurl=https%3A%2F%2Fwww.researchgate.net%2Fpublication%2F228065266%2Ffigure%2Ffig1%2FAS%3A393637805477897%401470861974235%2FThe-schematic-structure-of-type-3-active-site-Hemocyanin-a-the-schematic-met-form.png&imgrefurl=https%3A%2F%2Fwww.researchgate.net%2Ffigure%2FThe-schematic-structure-of-type-3-active-site-Hemocyanin-a-the-schematic-met-form_fig1_228065266&docid=PhT9YwmZzmIFjM&tbnid=3iC-PH5bcx9sWM&vet=12ahUKEwiF0Zj1qZqGAxW8VKQEHU2fDSEQM3oECGoQAA..i&w=699&h=1187&hcb=2&ved=2ahUKEwiF0Zj1qZqGAxW8VKQEHU2fDSEQM3oECGoQAA

2 Tipos de Hemocianina

Nos Moluscos

Nos Artrópodes

- cooperatividade baixa - decâmeros, didecâmeros ou multidecâmeros - subunidade polipeptídica de 350 ou 400 kDa - dobra-se numa cadeia de sete ou oito unidades funcionais (FUs).

- cooperatividade alta - hexameros ou múltiplos de hexameros; - cada subunidade (ca. 72kDa) dobra-se em três domínios caracterizados por diferentes motivos de dobramento

Disponível em: Imagem da esquerda- código PBD: 1LNL Imagem da direita- código PBD: 1HCY

- absorção máxima a 340 e 580 nm na forma oxigenada - espectro de fluorescência e dicroismo circular semelhante

Outras funções da hemocianina

  • Atividade antiviral
  • Síntese de espécies de oxigénio reativas
  • Aglutinação microbiana/viral
  • Atividade semelhante à da fenoloxidase
Exemplos:

A hemocianina purificada da hemolinfa de crustáceos, não só demonstra comportamento de aglutinação, como também exibe atividade hemolítica contra eritrócitos de mamíferos.

Quelicerados como aranhas e escorpiões não possuem uma fenoloxidase específica e, nesses animais, a hemocianina ativada pode catalisar a síntese de melanina in vivo.

Disponível em: https://t1.ea.ltmcdn.com/pt/posts/8/9/8/o_escorpiao_imperador_como_animal_de_estimacao_3898_600.jpg

Disponível em: https://veja.abril.com.br/wp-content/uploads/2016/05/ciencia-lagostim-crawfish-20140613-001-original1.jpeg?quality=90&strip=info&w=720&h=440&crop=1

Perspetivas futuras

Disponível em:https://blog.appegada.com/thumb/blog/1/780/500/7575009315e43cea8ab4b35117df03c2.jpghttps://www.ufms.br/wp-content/uploads/2023/06/8e94623a-bd03-452a-8891-cf9c3aa8c2a3.jpeg https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcQclqZ4aqUuZNgQC27kduzmYJMg2ZpTXPuOISsZwcUVfE8V3mJRr-bXlDBu-0Iwqef6Ayg&usqp=CAU https://www.sabrinabedin.com.br/wp-content/uploads/2019/08/imunoterapia.jpg

Bibliografia

  • Coates, C. J., & Nairn, J. (2014). Diverse immune functions of hemocyanins. Developmental and comparative immunology, 45(1), 43–55. https://doi.org/10.1016/j.dci.2014.01.021
  • Decker, H., Hellmann, N., Jaenicke, E., Lieb, B., Meissner, U., & Markl, J. (2007). Minireview: Recent progress in hemocyanin research. Integrative and comparative biology, 47(4), 631–644. https://doi.org/10.1093/icb/icm063
  • Banday, A. H., Jeelani, S., & Hruby, V. J. (2015). Cancer vaccine adjuvants--recent clinical progress and future perspectives. Immunopharmacology and immunotoxicology, 37(1), 1–11. https://doi.org/10.3109/08923973.2014.971963
  • Won, K. A., & Spruck, C. (2020). Triple‑negative breast cancer therapy: Current and future perspectives (Review). International journal of oncology, 57(6), 1245–1261. https://doi.org/10.3892/ijo.2020.5135
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  • Ruiyang Ji, Leying Guan, Ziyan Hu, Yishen Cheng, Meng Cai, Guanghua Zhao, Jiachen Zang, A comprehensive review on hemocyanin from marine products: Structure, functions, its implications for the food industry and beyond, International Journal of Biological Macromolecules, Volume 269, Part 1, 2024,132041, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2024.132041.
  • Li, J., Zhao, M., Zhang, X., Zheng, Z., Yao, D., Yang, S., ... & Aweya, J. J. (2023). The evolutionary adaptation of shrimp hemocyanin subtypes and the consequences on their structure and functions. Fish & Shellfish Immunology, 109347.
  • Malik, J. A., & Agrewala, J. N. (2023). Future perspectives of emerging novel drug targets and immunotherapies to control drug addiction. International Immunopharmacology, 119, 110210.
  • Vassilakopoulou, V., Karachaliou, C. E., Evangelou, A., Zikos, C., & Livaniou, E. (2021). Peptide-based vaccines for neurodegenerative diseases: Recent endeavors and future perspectives. Vaccines, 9(11), 1278.
  • Usman, M. B., Bhardwaj, S., Roychoudhury, S., Kumar, D., Alexiou, A., Kumar, P., ... & Jha, N. K. (2021). Immunotherapy for Alzheimer’s disease: current scenario and future perspectives. The journal of prevention of Alzheimer's disease, 1-18.
  • Ellerton, H. D., Ellerton, N. F., & Robinson, H. A. (1983). Hemocyanin—a current perspective. Progress in Biophysics and Molecular Biology, 41, 143-247.
  • Magnus, K. A., Ton-That, H., & Carpenter, J. E. (1994). Recent structural work on the oxygen transport protein hemocyanin. Chemical reviews, 94(3), 727-735.