MAGNETIC BOARD QUIZ

Medications and Human Milk quiz game

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Question 1/10

What are Enteral, Sublingual, Inhalation, Parenteral and subcutaneous?

Methods of feeding

Parts of the body

Routes of drug administration

Type of holiday

Right!

Different types of drug andministration can impact how much drug passes into the human milk and reach the baby

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Question 2/10

A drug with high oral bioavalability is more likely to reach the newborn circulation and be absorbed. Why?

Because all the drugs that pass into the human milk, are transferred to the baby orally

Because the baby's GI is immature

Because baby has big tongue to absorbe the drug

Because high oral bioavalability means that the mouth absorbes the drug

RIGHT!

Oral Biovalability means a drug is able to mantain its farmacological proprerties when passing the GI tract. All the drugs transferred to baby pass the GI tract with human milk.

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Question 3/10

Passive diffusion is the most common mechanism of transfer for drugs from bloodstream to milk. When can passive diffusion happen more easily?

After a c/section beacause mum receives more drugs

During galactopoiesis (lactogenesis III)

Before lactogenesis II because junctions among lactocytes are wider

When mum is dihydrated because blood is more concentrated

Right!

Closure of tight junctures among cells happens around 36 hrs post delivery (lactogenesis II). With closure, transfer is greatly reduced

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Question 4/10

If maternal plasma levels increase so does the concentration in the HM. As soon as the maternal plasma level has fallen, the milk level soon follows. How is this property called?

Pump diffusion

Milk transfer

Milk/Plasma ratio

Active diffusion

RIGHT!

Milk/ plasma ratio. If high (> 1-5), it is useful as an indicator of drugs that may sequester in milk in high levels. If low (<1), it is good indicator that only minimal levels of the drug are transferred into milk.

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Question 5/10

Do you think the drug molecolar weight has an impact on its ability to be transfered into human milk?

No, the molecular weight doesn't have an impact on the transfer

Yes, the smaller is the molecole weight the easier can pass into human milk

Yes, the larger is the molecular weight the easier can pass into the human milk

Molecular weight is derectly proportional to transfer into human milk

Right!

The smaller the molecular weight (< 300 Daltons) the easier is the rate of diffusion across the layer lipid membrane of the lactocytes.

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Question 6/10

Plasma concentrations of lipids is very low compared to 5-15% of triglycerides found in HM. Knowing this statament which sentence do you think is true?

Lipid suluble drugs easily dissolve into plasma

Triglicerids makes difficult the diffusion of drug in HM

The more lipid soluble the medication is the more it will transfer into HM

Triglicerides will transfer from HM to plasma

RIGHT!

The more lipid soluble is the medication and the more it will transfer into HM

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Question 7/10

Why the protein binding of the medication is an important factor to consider when evaluate prescription of a medication during breastfeeding?

The bound with a protein makes more difficult transfer into HM

Binding with a protein inactivate the drug molecule

It doesn't matter as it doesn't impact on the transfer into HM

If bound with a protein the drug molecule can easily pass into HM

RIGHT!

Free unbound drug diffuses readily, while highly protein-bound drugs like are unable to diffuse in significant amounts in HM

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Question 8/10

Pharmacogenomics is:

The study of how genes affect a person's response to drugs

Dose of the drug that is terapeutic in pregnant women

Way of administration of a drug

Time of elimination of a drug

RIght!

People metabolise drungs in different way due to different genes activity.

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Question 9/10

Why drugs with long half life are more likely to be found into HM?

Because maternal body doesn't absorbe the drug

Because they get absorbed by fat tissue

Drugs with short half life are more likely to be trasferred into HM

Because they stay into the maternal body for longer

RIGHT!

The shorter the better: a short half life means that the drug stays in the plasma and in the HM for less time and it is eliminated by the baby’s body more quickly

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