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Learn about our new centre and help us make it a great place to work and visit

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This version of the ION-DRI Building Guide is in beta mode. This means that it is still a work-in-progress and incomplete, while we continue to develop new ways of working. We will continue to update this guide, as we have more information.We are working to ensure that the guide is accessible to everyone, but in this testing phase,if you require an accessible version of the guide, please download the word document.If you have suggestions, or ideas to improve this guide, please let us know

A world-class research and treatment centre to fight neurological diseases – now the world’s leading cause of disability

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Our community Our vision Culture and collaboration A place for everyone Sustainability Our supporters

Our world-class centre brings together research and treatment services to understand and overcome neurological disease, which is now the largest cause of disability. We bring research scientists, clinicians and patients together to share knowledge and build deeper insights between people with neurological disorders, their doctors and the research community. Use this guide to learn more about our culture and community, the services that we offer, how to visit us, a guide to all the floors and rooms and stories about how different people are using the centre.A collaborative space for UCL Queen Square Institute of Neurology, the UK Dementia Research Institute and the National Hospital for Neurology and Neurosurgery (part of University College London Hospitals NHS Foundation Trust).

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“Our vision is to create the world’s leading centre for translational neuroscience. A brand new state-of-the-art facility will accelerate the discovery of new treatments, train the next generation of scientists and work in close partnerships with industry, funders and patients.”

Professor Alan Thompson Programme SponsorDean, Faculty of Brain Sciences

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“This will be a fantastic 21st century interdisciplinary environment designed to support our world-leading scientists to understand disease mechanisms and translate this knowledge into new therapies in a collaborative effort we call UCL Translational Neuroscience. “The co-location of clinical and basic scientists and patient care will build on the major success of the UCL Queen Square Institute of Neurology partnership with the National Hospital for Neurology and Neurosurgery (part of UCLH) by enabling patient observations to inform scientific questions. “It will be a beacon of excellence for training the next generation and will facilitate critical partnerships with all stakeholders including patient organisations, philanthropists and industry.”

Professor Michael Hanna Director, UCL Queen Square Institute of Neurology

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“We are at a tipping point in dementia research, on the cusp of some major breakthroughs that will accelerate progress towards new treatments for patients. While this new building and all it stands for is truly exciting, it’s what will happen inside it that is even more thrilling to me. “The opportunities for collaborations and partnerships between discovery scientists and clinicians, together with access to world-class facilities, will undoubtedly have a huge impact. “This state-of-the-art centre will serve to speed up the delivery of new treatments, tools and diagnostics, bringing us ever closer to achieving the UK Dementia Research Institute’s mission of improving the lives of people affected by dementia and other neurodegenerative diseases.”

Professor Siddharthan ChandranDirector, UK Dementia Research Institute

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“The new Queen Square Institute of Neurology and Dementia Research Institute development allows for the integration of world-class clinical services from the National Hospital for Neurology and Neurosurgery, with state-of-the-art scientific facilities from UCL, to bring modern treatments for neurological conditions directly to patients. “This is an exciting time for the management of devastating neurological diseases bringing hope to many people throughout the UK and the rest of the world.”

Dr Chris Turner Divisional Clinical Director, National Hospital for Neurology and Neurosurgery, UCLH

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We’re pioneering a new way of working together, with unrivalled opportunities for multidisciplinary collaboration. Together we hope to create the most comprehensive and coordinated neuroscience research hub in the world.Collaboration is at the heart of our new facility, with shared spaces, central equipment and services that everyone can access. There is a range of workspaces, including meeting rooms, collaboration places, and informal seating areas and coffee points, where bumping into colleagues from across the institute is encouraged.

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A public café, roof terrace, garden and outside benches offer more opportunities to get together and share expertise.The outpatient department for the National Hospital for Neurology and Neurosurgery (NHNN) and shared UCL and UCLH MRI suite puts researchers, clinicians and patients under one roof for the first time. This builds on our collaborative approach at Queen Square House, where scientists work side by side with NHNN’s inpatient wards, day care, operating theatres and intensive care.

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We’re committed to making 256 Grays Inn Road a welcoming place for everyone and our environment needs to support this.Our building has been designed in an inclusive, accessible and sustainable way, meeting and often exceeding, UCL and government accessibility regulations.

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The site is designed with accessibility in mind, including building entrances, circulation, outpatient areas and accessible toilets, with a changing place facility on the ground floor. We have looked at lighting, acoustics, décor, flooring, layout, wayfinding, thermal comfort and odour to ensure that everyone can enjoy working in the building. A flexible design ensures that individual needs can be accommodated and a range of spaces are available to support people with different needs, including a maternity, quiet room and faith space. Hearing induction loops are available in all meeting rooms and reception areas.

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Sustainability is fundamental to our vision. We are committed to reducing our impact on the environment through our building, our processes and the way we work. As well as reducing carbon emissions, lowering energy and water use and minimising waste, we have aimed to create a healthy, comfortable, inclusive and safe building that supports visitors’ and staff wellbeing and provides the best possible environment for world-class research.

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Green spaces and new communal areas include a roof terrace, public café and sensory garden. We have also worked to ‘future-proof’ the building in a flexible design that can accommodate changes in the needs of the development over time.

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The building is funded byPhilanthropic partners Iceland Foods Charitable FoundationWolfson FoundationGarfield Weston FoundationMr Martin Lee and Mrs Cathy LeeNational Brain AppealBrain Research UKand moreFounding Funders of the UK Dementia Research Institute Medical Research CouncilAlzheimer’s SocietyAlzheimer’s Research UK

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Public areas and UCLH Outpatients – G

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Click on the sections above to find out more about our services and facilities, or use the floor by floor guide to see an overview of services on each level

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Each laboratory floor has primary lab, and write-up spaces, dedicated to individual research groups, alongside shared cellular lab spaces, a lab lobby, offices and a communal areaThe communal areas include:

  • a professional services team space, where research staff can go to ask questions and get help
  • Shared kitchen areas, including a microwave, fridge, dishwasher, hot and cold filtered water, crockery, cutlery and glassware
  • Printers and photocopying facilities
  • A range of informal drop-in spaces and seating areas, including quiet areas to hold small meetings and conference calls
  • A shared office supplies and stationery point, stocked with commonly-used items for use by staff from teams based in the building
Keypad-operated lockers are located in write-up areas. There is capacity for all ION and UK DRI staff to access a locker for personal storage, on a day-to-day basis.

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Each laboratory floor has primary lab, and write-up spaces, dedicated to individual research groups, alongside shared cellular lab spaces, a lab lobby, offices and a communal areaThe communal areas include:

  • a professional services team space, where research staff can go to ask questions and get help
  • Shared kitchen areas, including a microwave, fridge, dishwasher, hot and cold filtered water, crockery, cutlery and glassware
  • Printers and photocopying facilities
  • A range of informal drop-in spaces and seating areas, including quiet areas to hold small meetings and conference calls
  • A shared office supplies and stationery point, stocked with commonly-used items for use by staff from teams based in the building
Keypad-operated lockers are located in write-up areas. There is capacity for all ION and UK DRI staff to access a locker for personal storage, on a day-to-day basis.

Work spaces Core facilities Shared lab facilities Site facilities Public areas NHS services

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Workspaces

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IT Facilities

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Meeting spacesWe have a range of bookable meeting rooms in the building, across all floors, equipped with conference-call facilities, wireless screen sharing, wall-mounted display screens, integrated camera microphone sound bar or array microphone, camera and ceiling speakers for induction loop.Touch panels on meeting room tables will allow people to join meetings and a room-scheduling panel outside shows people if a room is reserved. Meeting rooms can be booked by any UCL or UKDRI member of staff via Outlook 365Zoom-enabled roomsWe have three in total: two located on the ground floor of the Alexandra Wing (6 and 8 person) for UKDRI staff, one locatedon the second floor (6 person).Teams-enabled roomsLocated on level 2 (2 x 5 person and 1 x 6 person)

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NHS connectionsGround floor meeting rooms will include cabled NHS connections. The level 2, zoom-enabled room and Level 1 conference room will connect to NHS wi-fi via Wi-Fi emitters.Meeting boothsWe have six smaller meeting booths (4 person) on levels 1 and 2, fitted with a screen, HDMI and USB-C cables and power sockets.Board rooms

  • Level 1: Zoom and Teams-enabled board room (22+ capacity)
  • Level 3: Teams-enabled boardrooms (14 person)
  • Level 4 (14 person)
Lecture theatreWe have a 200-seat lecture theatreBreak-out areasWe have a range of drop-in spaces for non-confidential, informal meetings and one-on-ones on the social landing area.

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Work spaces Core facilities Shared lab facilities Site facilities Public areas NHS services

We have a number of core facilities and scientific services available, with high performance laboratory equipment and dedicated specialists on hand to help with your research needs. › Single cell analysis and transcriptomics› HiPSC › Cell imaging and microscopy › Tissue processing and analysis › Genetic therapy platform › MRI suite › Scientific IT› Bioinformatics› Genomics and High throughput sequencing › Biological Services Unit › Scientific Services: › Sample reception › Biorepository › Quarantine and quality control › Equipment maintenance › Sample processing › Laboratory and equipment sterilisation › Autoclaves / glasswash

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What Who How Why

WhatThe Single Cell and Transcriptomics Platform provides access to services and instruments to carry out single cell workflows using 10x Genomics technology and supported access to multiple instruments for carrying out spatial transcriptomics including Nanostring GeoMx and CosMx, Vizgen Merscope and BGI Stereoseq. The platform will aid researchers with bioinformatic analysis following data collection and can advise on the most effective downstream analysis and use of the data.

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Core facilities

Single cell analysis and transcriptomics

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Further info

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General enquiries Daria Gavriouchkina, Platform Manager Modesta Blunskyte, Platform Technician

Information to come.

Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

LEVEL B1

What Who How Why

Core facilities

Single cell analysis and transcriptomics

How

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Researcher contacts facility staff to discuss study design and feasibility.

Facility staff run study as a service or support researchers to use equipment themselves.

Data deposited onto a secure accessible server for visualisation, discussion and further analysis.

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Data transferred to researcher for long-term storage, with back up on platform server.

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WhoIt can be used by all research staff and students, following a consultation with the team

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Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

General enquiries Daria Gavriouchkina, Platform Manager Modesta Blunskyte, Platform Technician

LEVEL B1

Information to come.

What Who How Why

Core facilities

Single cell analysis and transcriptomics

Why

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A dedicated technical team in place to support youAccess to cutting-edge technologies without having to invest in them yourselfExpert experimental workflows carried out accurately, using expensive reagentsReduces experimental variability between datasets, increasing reproducibilityBest data practices, using FAIR principles

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Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

General enquiries Daria Gavriouchkina, Platform Manager Modesta Blunskyte, Platform Technician

LEVEL B1

Information to come.

What Who How Why

WhatThe human induced pluripotent stem cell (iPSC) core can help with acquisition, expansion, banking and quality control of iPSC lines according to standardised protocols, in line with those recommended by the International Society for Stem Cell Research (ISSCR). Custom projects, including reprogramming, iPSC differentiation into 2D and 3D cultures and gene-editing, will be available on a service or collaborative basis depending on capacity and researcher preferences, to be arranged by discussion. The core can also provide standardised protocols and training for individual researchers in iPSC culture methods.

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HiPSC

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This is a chargeable service and usage will need to be paid for via project code

Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

LEvel B1

What Who How Why

Core facilities

HiPSC

How

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Researcher contacts the facility for an informal discussion about their project and individual requirements.

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Newly generated or received iPSC will be expanded and a frozen bank of cells will be generated.

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Quality control of new iPSC will be performed including mycoplasma testing, pluripotency marker expression, verification of mutation status and karyotyping.

Selected projects, including custom differentiation, reprogramming and gene editing will be designed on an individual basis with the researcher.

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Cost

Researchers will either be able to pay a fee for this service, or act as a ‘stem cell hotel’ where they can work in situ in the core facility to receive the necessary training or access the facility as a ‘stem cell hotel.

WhoFor all research staff and students

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Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

General enquiries Daria Gavriouchkina, Platform Manager Modesta Blunskyte, Platform Technician

This is a chargeable service and usage will need to be paid for via project code

LEvel B1

What Who How Why

Core facilities

HiPSC

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A dedicated technical team in place to support youStandardised protocols and quality control procedures ensuring the highest quality cell linesCost effectiveness through batch ordering of media and reagentsAccess to resources through cataloguing of iPSC available at Queen Square Institute of Neurology

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Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

General enquiries Daria Gavriouchkina, Platform Manager Modesta Blunskyte, Platform Technician

This is a chargeable service and usage will need to be paid for via project code

LEvel B1

What Who How Why

WhatOur Cell Imaging and Microscopy platform provides state-of-the-art light microscopy facilities and image analysis software, as well as a dedicated team to support researchers throughout the process of imaging.From planning a project, sample preparation and selecting an appropriate microscope, to image processing and visualisation, data transfer and storage, the imaging rooms will provide facilities for quantitative investigations of fixed and live cell and tissue samples.Imaging systems include spinning-disk and scanning confocal microscopes, STED and Airyscan super-resolution systems, brightfield and fluorescence microscopes for longitudinal studies of live samples, and multi-photon systems for deep tissue and intravital imaging.

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Cell imaging and microscopy

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This is a chargeable service and usage will need to be paid for via project code

Further information Detailed technical specifications for all the microscopes, and associated charging rates, can be found here

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Dr Nic Cade

What Who How Why

Core facilities

Cell imaging and microscopy

How

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Researchers contact facility staff to discuss their sample, imaging requirements, and overall workflow.

Our facility staff will train researchers on recommended systems and equipment to acquire and analyse their data.

Most researchers will be supported to acquire their own data independently, but in some cases, facility staff can assist with microscopy and image analysis projects, chargeable at a set rate.

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WhoIt can be used by all research staff and students. Our services can also be used by visitors and external users on request

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This is a chargeable service and usage will need to be paid for via project code

Dr Nic Cade

Further information Detailed technical specifications for all the microscopes, and associated charging rates, can be found here

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Core facilities

Cell imaging and microscopy

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A dedicated imaging team in place to support you including an image analysis specialist to support with downstream image processing.A range of training sessions on offer, including one-on-one, ad hoc and group sessionsEquipment maintained and serviced centrally and regularly upgraded or replaced to keep up with the latest technological developments

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Dr Nic Cade

This is a chargeable service and usage will need to be paid for via project code

Further information Detailed technical specifications for all the microscopes, and associated charging rates, can be found here

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What Who How Why

WhatOur on site tissue processing and analysis facility provides a dedicated area, designed and equipped to support a range of histological methods, including tissue processing, sectioning and staining. We offer a range of facilities to support tissue dissection, processing for cryostat, wax or vibratome sectioning, manual and automated ICC and IHC staining systems, including RNAScope with automated cover-slipping, and light microscopy.You’ll have access to state-of-the-art equipment maintained to a high standard, ensuring high quality studies, as well as opportunities to collaborate with other researchers, building on existing networks and developing additional skills through cross training.

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Tissue processing and analysis

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TBC

Further information More information, including standard operating procedures and access will be available to download.

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TBC

What Who How Why

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Tissue processing and analysis

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WhoIt can be used by all UCL research staff and students

How

Researchers can arrange access to the tissue processing facility via our lab manager, for an annual charge per person.

Access includes use of the lab, equipment, common consumables, and support from the lab manager. (Additional volume charges only applied to the Ventana and Sakura processors).

Equipment such as the cryostats, microtomes, vibratome and automated processors will be bookable.

There is also some open lab bench space for researchers to conduct manual IHC experiments.

The Histology lab manager will be responsible for maintaining the equipment, re-stocking common consumables, overseeing the equipment booking system, training, H&S, and support with troubleshooting.

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Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

TBC

TBC

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Core facilities

Tissue processing and analysis

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A dedicated technical team in place to support youAccess to the latest equipment, without having to invest in it yourselfBest practice and relevant training opportunities on handOpportunities to collaborate and expand your network

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TBC

TBC

LEVEL B1

What Who How Why

WhatOur Genetic Therapy Vector core facility (GTVC) uses cutting-edge technologies to create and produce a variety of high quality adeno-associated viral vectors (AAV) to provide researchers with the most suitable and efficient gene transfer vectors for their research applications. The facility will provide a catalogue of reporter gene AAV vectors, available to order; a Capsid packaging service, a custom gene therapy design and production and training.

Core facilities

OUR FACILITIES

Genetic therapy platform

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Cost

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TBC

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LEVEL 2

TBC

What Who How Why

Core facilities

Genetic therapy platform

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WhoAvailable to all research staff and students. Only fully trained research staff, including staff from Genetic Therapy Accelerator Centre will be able to use the facility’s equipment themselves.

How

Researchers contact our facility staff to select which service is most appropriate to your research project, the quantities of vector required and timeline.

Researchers can choose from ordering AAV from our catalogue, providing construct for AAV capsid packaging, a custom designed gene therapy programme carried out by facility or, in some cases, receive training to access the facility yourselves.

Our team will produce and titrate the vector, ready for collection.

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TBC

LEVEL 2

What Who How Why

Core facilities

Genetic therapy platform

OUR FACILITIES

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Location

Further info

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Cost

Why

Dedicated Genetic therapy team to produce high quality AAV vectorsConsistent AAV production methodology in production, titration and purificationHigh level of AAV vector characterisation and quality control availableAccess to expert researchers to support custom-design of AAV vectors for research needs

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TBC

TBC

LEVEL 2

What Who How Why

WhatOur state-of-the-art MRI facility is shared between UCLH and UCL and will house five Siemens 3T MRI scanners. These scanners will complement our existing research 3T MRI neuroimaging facilities at Queen Square and provide additional MRI capacity for cohort studies and trials, as well as for translational imaging methods research led by Queen Square Institute of Neurology investigators and key UCL collaborators. Managed by a UCLH team, the MRI suite will have four UCLH scanners and one UCL scanner available for use. The facility will be used for NHS patient appointments, with UCL researchers able to use one fifth of the available scanning capacity within the facility

Core facilities

MRI suite

OUR FACILITIES

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Contact

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Cost

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Further info

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ABOUT THE CENTRE

This will be a chargeable service. Rates will be published shortly.

Further information To come

LEVEL B1

Tarek Yousry

What Who How Why

Core facilities

MRI suite

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VISITING THE CENTRE

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Cost

WhoThe service will be available for both NHS patient and research use. The UCL scanner will be available to ION teams and across UCL, depending on capacity.

How

The service will provide 4 x Siemens CIMA.X 3T scanners and 1 x Siemens Vida 3T scanner

The service will be bookable and managed by a UCLH operational team

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Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

This will be a chargeable service. Rates will be published shortly.

Tarek Yousry

LEVEL B1

What Who How Why

Core facilities

MRI suite

OUR FACILITIES

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Location

Further info

Contact

Cost

Why

A central facility with the latest scanning technologySeamlessly concatenate clinical and research scans, minimising patient inconvenience, essential to avoid attrition in longitudinal studiesA dedicated technical team will be in place to support and run the facility Competitive rates aligned with existing UCL scanning costs Provides essential additional capacity

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This will be a chargeable service. Rates will be published shortly.

Tarek Yousry

LEVEL B1

What Who How Why

WhatWe will have a range of facilitated data science services that connect and support the activities of researchers, including storage of research data, computational data analysis and data stewardship.More information to follow.

Core facilities

Scientific IT

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Contact

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Cost

Further info

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This will be a chargeable service and rates will be published shortly

Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

Declan Chard

What Who How Why

Core facilities

Scientific IT

OUR FACILITIES

VISITING THE CENTRE

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Home

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Cost

WhoFor all UCL research staff at Queen Square Institute of Neurology and UK Dementia Research Institute, with a permanent base at Grays Inn Road or Queen Square - whether working on site, elsewhere at UCL or remotely.

How

We are currently working with the UCL Advanced Research Computing team (ARC) to finalise details

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Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

This will be a chargeable service and rates will be published shortly

Declan Chard

What Who How Why

Core facilities

Scientific IT

OUR FACILITIES

VISITING THE CENTRE

EVERYDAY STORIES

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Home

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Further info

ABOUT THE CENTRE

Contact

Cost

Why

Opportunity to combine scientific data from different fields / disciplines to build a rich, layered perspective Easy retrieval of data with improved possibilities to share research outside UCL e.g. with researchers in other locations, universities or upload to online repositoriesTime savings of adopting a unified platform and hardware approach as opposed to having multiple locations/servers etc. Authentication security via UCL credentials and compliance with data security legislation Archiving standards and multiple offsite backups (mitigating risk of data loss locally) Industry standard corporate hardware and a team of professionals to configure for optimum performance

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Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

Declan Chard

This will be a chargeable service and rates will be published shortly

What Who How Why

WhatInformation to follow

Core facilities

OUR FACILITIES

Bioinformatics

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Contact

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Cost

Further info

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TBC

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TBC

What Who How Why

Core facilities

Bioinformatics

OUR FACILITIES

VISITING THE CENTRE

EVERYDAY STORIES

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Further info

Home

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Contact

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Cost

WhoInformation to follow

How

Information to follow

Information to follow

Information to follow

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TBC

TBC

What Who How Why

Core facilities

Bioinformatics

OUR FACILITIES

VISITING THE CENTRE

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Home

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Further info

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Contact

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Why

Information to followInformation to followInformation to followInformation to follow

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TBC

TBC

WhatInformation to follow

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OUR FACILITIES

What Who How Why

Core facilities

VISITING THE CENTRE

Genomics and High throughput sequencing

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Home

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Further info

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Contact

Cost

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TBC

TBC

LEVEL 1

WhoInformation to follow

How

OUR FACILITIES

VISITING THE CENTRE

EVERYDAY STORIES

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Home

Information to follow

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Information to follow

Information to follow

What Who How Why

ABOUT THE CENTRE

Core facilities

Genomics and High throughput sequencing

Further info

Contact

Cost

Location

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TBC

TBC

LEVEL 1

What Who How Why

Core facilities

Genomics and High throughput sequencing

OUR FACILITIES

VISITING THE CENTRE

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Home

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Location

Further info

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Cost

Why

Information to followInformation to followInformation to followInformation to follow

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TBC

TBC

LEVEL 1

WhatOur facility, part of UCL Biological Services, contributes to the advancement of biomedical research through the supply of high-quality research animals and services. Our primary service is housing and husbandry services for animals used in research, including oversight of the establishment licence, provision of Named Veterinary Surgeons and Home Office liaison. Animal welfare is top priority and our Named Animal Care and Welfare Officers (NACWOs), work with our Named Veterinary Surgeons (NVSs) to ensure we operate to the highest standards of care. Further services include access to shared procedural and surgical spaces, animal sourcing, technical support, licensing and training. An additional research platform – Transgenic Services – offers creation, manipulation and delivery of genetically modified embryonic stem cell lines and mouse models.

Core facilities

Biological Services Unit

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What Who How Why

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TBC

Biological Services Admin

Further information For more information on Biological Services at UCL, visit us here.

WhoOpen to all research staff and students with the appropriate Home Office licence for their research and associated grant

How

OUR FACILITIES

VISITING THE CENTRE

EVERYDAY STORIES

Researchers contact our facility staff to discuss research projects and explore available options.

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Researchers must be inducted and trained in relevant techniques before gaining access and carrying out their experiments.

Home

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Core facilities

Biological Services Unit

ABOUT THE CENTRE

What Who How Why

Further info

Contact

Cost

Why

On site state-of-the-art facilities, with a dedicated technical team in place to support youStandardised services carried out in accordance with industry best practiceHighest standards of animal welfareSurpluses are reinvested into equipment and services

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TBC

Biological Services Admin

Further information For more information on Biological Services at UCL, visit us here.

What Who How Why

WhatOur specimen reception laboratory is the first point of call for all sample management activities including biorepository, cryogenic storage, sample processing and sample quarantine and quality control.The reception will manage the entire process, creating a complete sample management pipeline, receiving samples directly from clinics, processing them according to need and delivering sample requests back to researchers.Staffed by a dedicated technical team, the reception will receive all incoming samples to Grays Inn Road, including from internal research teams and external collaborators.

Core facilities

Scientific Services

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EVERYDAY STORIES

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Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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TBC

Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

LEVEL B1

TBC

Core facilities

Scientific Services

WhoFor all research staff / students, core facility managers and technical service staff

OUR FACILITIES

How

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Incoming samples for biorepository storage, cryostorage or sample processing should be directed to the specimen reception.

Full details of how to submit samples, including transportation are available (LINK)

ABOUT THE CENTRE

All accepted samples will be registered, tracked, barcoded and directed to storage, processing, quarantine or quality control, as appropriate.

What Who How Why

Contact

Cost

Location

Further info

All samples will be available to view on the IoN sample management system, as part of a catalogue of all sample holdings.

Researchers can search samples via the catalogue and request access. Approval will need to be given before access is granted.

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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TBC

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TBC

LEVEL B1

Core facilities

Scientific Services

OUR FACILITIES

VISITING THE CENTRE

EVERYDAY STORIES

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Why

Home

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ABOUT THE CENTRE

Single point of entry for all incoming samples with standardised sample accessioning and sample management processesEstablishes a transparent chain of custody throughout the entire sample lifecycle, from point of origin to receipt, storage, utilisation and disposalKey coordination centre for all sample management and quality control operationsSupports UCL compliance with Human Tissue Act legislation

What Who How Why

Contact

Cost

Location

Further info

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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TBC

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TBC

LEVEL B1

What Who How Why

WhatOur biorepository is a central facility to manage, track and store biospecimen holdings from across the institute comprising a dedicated sample reception area and a single sample management system.Working in conjunction with the sample processing and quality control facilities, the biorepository enables a transparent chain of custody throughout the entire sample lifecycle, from point of origin to receipt, storage, utilisation and disposal. This will ensure that samples are of consistent quality and appropriate for the intended analytical objectives. The biorepository will also support ultra low temperature (ULT) and cryogenic sample storage, as part of the ULT storage facility

Core facilities

Scientific Services

Contact

OUR FACILITIES

VISITING THE CENTRE

EVERYDAY STORIES

Cost

HELP CENTRE

Location

Further info

Home

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Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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EVERYDAY STORIES

VISITING THE CENTRE

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TBC

Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

LEVEL B1

TBC

Core facilities

Scientific Services

WhoFor all research staff / students, core facility and central service staff.

How

OUR FACILITIES

VISITING THE CENTRE

The sample reception area will receive and record all incoming and outgoing samples, for cataloguing, barcoding, onward processing and storage.

A single sample management system will barcode, track, catalogue and enable access requests to be processed through dedicated staff (subject to approval).

EVERYDAY STORIES

Before staff move into Grays Inn Road, existing samples will be identified, catalogued and transferred to dedicated storage facilities.

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What Who How Why

Home

Contact

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Cost

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ABOUT THE CENTRE

Widens and streamlines access to patient-derived biological samples through a transparent sample catalogue and request / approval process.

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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TBC

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TBC

LEVEL B1

Core facilities

OUR FACILITIES

Why

VISITING THE CENTRE

EVERYDAY STORIES

HELP CENTRE

Improved sample quality by standardising processing and quality managementProvides a platform to share experimental data to aid collaboration and reduce experimental duplication

Home

What Who How Why

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Contact

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Cost

Location

Further info

Scientific Services

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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TBC

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TBC

LEVEL B1

What Who How Why

WhatOur quarantine and quality control laboratories are an institute-wide resource that will enable incoming cell samples to be separated from tissue culture facilities until it has been determined that those samples are free of contaminants. The quarantine facility can also be used to treat irreplaceable samples that have been shown to be contaminated.The quarantine facility is configured as a standard tissue culture laboratory with all necessary equipment provided, whereas the quality control lab will additionally incorporate equipment to monitor mycoplasma contamination and to perform STR profiling experiments.

Core facilities

OUR FACILITIES

Scientific Services

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EVERYDAY STORIES

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Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

LEVEL B1

Initial screenings centrally-funded, with research groups covering costs once at Grays Inn Road

Lee Stanyer

Core facilities

Scientific Services

OUR FACILITIES

VISITING THE CENTRE

WhoFor all research staff and students, as well as core facility and central service staff.

EVERYDAY STORIES

How

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Each research group will need to consolidate existing cell stocks and identify samples for screening approx. three months ahead of moving to Grays Inn Road.

A dedicated cell screening technician will batch test samples for contamination status and cell purity.

Samples that have been approved by quality control (QC) will be released for use in tissue culture facilities.

What Who How Why

Contact

Cost

Location

Further info

Once established at Grays Inn Road, routine monitoring of mycoplasma status should take place fortnightly.

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

Initial screenings centrally-funded, with research groups covering costs once at Grays Inn Road

Lee Stanyer

LEVEL B1

Core facilities

Scientific Services

OUR FACILITIES

VISITING THE CENTRE

Why

EVERYDAY STORIES

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Quality assurance for samples being used in shared tissue culture laboratories and in cryogenic storage, and for cells being transferred to partner institutions and collaboratorsDedicated facilities and standardised methods for sample quality controlContaminated samples can be quickly separated from other work and treated if necessary

What Who How Why

ABOUT THE CENTRE

Contact

Cost

Location

Further info

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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EVERYDAY STORIES

VISITING THE CENTRE

OUR FACILITIES

ABOUT THE CENTRE

Initial screenings centrally-funded, with research groups covering costs once at Grays Inn Road

Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

Lee Stanyer

LEVEL B1

What Who How Why

WhatWe are using Infinity X, an asset management software, to log all ION’s equipment and help manage equipment maintenance across the institute. Researchers can easily report equipment faults, schedule maintenance activities, set-up maintenance alerts to designated staff members, as well as find a variety of documents associated with each equipment item, including operating manuals, service reports, standard operating procedures (SOPs) and troubleshooting manuals.

OUR FACILITIES

Contact

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Home

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Cost

Further info

ABOUT THE CENTRE

Core facilities

Scientific Services

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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EVERYDAY STORIES

VISITING THE CENTRE

OUR FACILITIES

ABOUT THE CENTRE

Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

Lee Stanyer

To come

Core facilities

Scientific Services

OUR FACILITIES

VISITING THE CENTRE

WhoFor all research staff / students, core facility managers and technical services staff.

EVERYDAY STORIES

How

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Home

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ABOUT THE CENTRE

Researchers create an Infinity X account using single-sign-on (with their UCL credentials), which is verified by the departmental administrator.

Researchers can report equipment faults, via a technical fault tracker. This can either be accessed directly in the software or via the mobile app, by scanning the QR code attached to the equipment.

The issue will then be sent to a designated individual, typically the laboratory or core facility manager, to rectify. Users will be able to track the progress of their fault via the software.

What Who How Why

Contact

Cost

Further info

Lab managers will usually be responsible for equipment maintenance and they will receive notifications when a service visit needs to be scheduled.

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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ABOUT THE CENTRE

Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

Lee Stanyer

To come

Why

OUR FACILITIES

VISITING THE CENTRE

EVERYDAY STORIES

A more efficient solution to report, track and resolve technical equipment faultsStandardised procedures, and practices compliant with statutory testing regimesProvides a document archive for each item of equipment allowing service records, repairs, operating manuals to be accessed online

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What Who How Why

Home

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Contact

ABOUT THE CENTRE

Cost

Further info

Core facilities

Scientific Services

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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To come

Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

Lee Stanyer

What Who How Why

WhatOur sample-processing facility will provide a range of services for the pre-analytical processing of clinical and biological samples, including whole blood processing; serum and plasma extraction; urine and CSF processing; DNA/RNA extraction and sample aliquoting. In some areas, specific services will be outsourced to trusted third-party suppliers.The facility includes a specimen reception for sample registration and a sample processing laboratory, with clearly-defined standard operating and quality control procedures.Sample quality can often be affected by a variety of factors including the timing, collection, storage conditions and sample preparation techniques, so our facility will ensure samples across the centre are of a consistently high quality in order to support excellent and reproducible research.

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Contact

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Further info

ABOUT THE CENTRE

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Core facilities

Scientific Services

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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EVERYDAY STORIES

VISITING THE CENTRE

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Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

LEVEL B1

To come

TBC

Core facilities

Scientific Services

OUR FACILITIES

VISITING THE CENTRE

WhoIt can be used by all research staff and students

How

EVERYDAY STORIES

HELP CENTRE

Home

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ABOUT THE CENTRE

Researchers submit sample processing requests to a dedicated team.

The team respond with a price quotation

Samples are shipped directly to the specimen reception for onward processing.

What Who How Why

Contact

Cost

Location

Further info

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

Why

A more efficient solution to transport, organise, track and process clinical samples throughout their lifecycleImproved sample quality by standardising processing and quality managementA simplified process: consolidating existing procedures into one processTime and costs savings via high throughput services and economies of scale

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LEVEL B1

What Who How Why

WhatWe have a biological decontamination service on site for the routine sterilisation of cellular laboratory spaces and scientific equipment. A cyclical and scheduled programme of vaporised hydrogen peroxide (VHP) fumigation will focus on contamination prevention but will also be reactive should random contamination events occur. This service will use portable VHP generators for cellular spaces requiring a semi-sterile environment, such as tissue culture, molecular biology and microbiology laboratories. It will also be possible to sterilise scientific equipment using a large pass-through VHP chamber located on level B2. The service will also be available on request for other laboratory areas, depending upon their suitability for fumigation.

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Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

WhoFor all research staff / students, laboratory manager, core facility managers and technical service staff.

How

An annual programme of VHP sterilisation will be available to all staff and students to allow sufficient forward planning to vacate areas planned for fumigation.

On specified dates, laboratories will be decontaminated using portable VHP generators that are programmed for VHP release, subsequent aeration and then tested for cycle effectiveness using biological and chemical indicators.

The service will be flexible to allow for any urgent requirements and will be bookable upon request.

Equipment sterilisation using the VHP chamber can be booked individually using a service request form.

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Scientific Services

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

Why

Provides a service aimed at contamination prevention rather than being reactionary. The use of VHP is a more rapid and convenient method of fumigation than alternative methods, is less sensitive to temperature variation and is significantly less hazardous to human health. The service can be deployed rapidly thus reducing downtime associated with contamination events. Service costs are significantly cheaper than employing a third-party decontamination provider.

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What Who How Why

WhatThe autoclave and glasswash is a large capacity, centrally-managed facility to meet all laboratory disinfection, sterilisation and waste treatment needs. The facility will provide a comprehensive service for the disinfection of laboratory glassware, sterilisation of liquids, surgical instruments, labware and waste products.We’re equipped with 3 Steelco autoclaves, each with a capacity of 920 litres, and 3 Miele glasswashers with integrated drying cabinets. Each machine provides a variety of programmable cycles to meet a range of needs, with data collected and retained on all cycles for quality assurance purposes.

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Scientific Services

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

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WhoIt can be used by all research staff and students

How

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Leave dirty items at the checkpoint on each lab floor.

Our glass-wash team collects items regularly throughout the day.

Items taken to glasswash facility on basement floor.

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Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

Clean items returned directly to lab floor.

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Why

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A dedicated technical team in place to support youNo need for individual laboratories and departments to provide their own autoclaves and glasswashersMore time for research staff and students to focus their efforts on research activitiesQuality controls and service level agreements in place to ensure an efficient serviceMarket standards in utilities efficiency, consuming low levels of energy and water

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Scientific Services

Sample receptionBiorepositoryQuarantine and quality control Equipment maintenanceSample processingLaboratory and equipment sterilisation Autoclaves / glasswash

A dedicated technical team in place to support youNo need for individual laboratories and departments to provide their own autoclaves and glasswashersMore time for research staff and students to focus their efforts on research activitiesQuality controls and service level agreements in place to ensure an efficient serviceMarket standards in utilities efficiency, consuming low levels of energy and water

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LEVEL B1

Work spaces Core facilities Shared lab facilities Site facilities Public areas NHS services

› Lab lobbies and storage› Chemical management› Microbiology› Shared equipment› Tissue culture› Molecular biology› Cold storage› Vending machines

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Work spaces Core facilities Shared lab facilities Site facilities Public areas NHS services

› Access and Security Reception Toilets› Changing facilities and showers› Lockers› Cycling facilities› Quiet Room, Multifaith room and maternity room› Parking and Drop off› Accessibility› Your comfort

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LAB LOBBIESEach open-plan laboratory, on floors 1–4, will be reached through a lab lobby, where researchers can collect PPE and have immediate access to first aid kits and plumbed-in eye washes. Vending machines, stocking a range of research consumables (4ºC, –20ºC and room temperature) will also be available in the lobby areas, with ice machines located on select floors. Researchers will be able to collect clean and autoclaved glassware from the lobby, as well as leaving dirty glassware for collection. Bins for clinical, recyclable and glass waste will also be available here.

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Lab lobbies and storage

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Lab lobbiesStorage

Lab lobbies and storage

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LAB STORAGEA range of storage facilities will be available on floor B1 to support the scientific community, including:Flammable storage: Stock flammables will be available from the store room, which will be monitored by a safety representative.Waste chemicals: A central storage area will act as a holding area for waste chemicals until they are collected by the UCL-assigned disposal company. Research teams and lab managers will be responsible for the waste stored in the waste chemical store until collected.Toxins: The toxin store will contain safety and storage facilities for all Class 5 toxins in pure form, which will be confined to this area, in addition to documentation tracing the usage of each stock. A buddy system will operate in this area. Access to this area will be granted on the authorisation of the Counter Terrorism Security Adviser (CTSA) and Institute Director. Buffer stock and on-floor storage: A range of consumables and stationery will be available from central and on-floor stores that will be managed via an inventory tracking system. Stocks will be regularly audited and cross-charged to research groups and departments.

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What Who How Why

WhatWe are using a chemical management software tool, ChemInventory to ensure all our specialist chemicals are effectively managed and access tightly regulated. This will standardise the management of specialist chemicals across Queen Square and 256 Grays Inn Road and all ION sites and make auditing easier.

Chemical management

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Chemical management

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WhoFor Lab Managers and selected research staff across all ION sites

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How

A unique barcode is affixed to chemical container on receipt by lab manager.

Lab manager updates online inventory with details of chemical name, barcode & storage location.

Product code and CAS number added to record links product to relevant material data safety sheet.

Chemicals are searchable on database by chemical name, CAS number, or barcode.

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Chemical management

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Why

Space-saving: consolidating specialist chemical holdings stored on-siteStandardised procedures, training and practices compliant with relevant legislationTime and costs savings via a single contract and ease of generating chemical returns dataRemoval of legacy chemicals prior to Grays Inn Road migration

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What Who How Why

WhatThe microbiology laboratory is a dedicated, institute-wide resource for plasmid preparation and the transformation, propagation and selection of microorganism species.A dedicated laboratory has been provided to isolate plasmid and microorganism species away from primary laboratory areas and to aid compliance with The Genetically Modified Organisms (Contained Use) Regulations, 2014The laboratory will provide a range of equipment including large capacity and benchtop shaking incubators, floor standing and benchtop centrifuges, fridges, freezers and benchtop accessory items.

Microbiology

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Researchers will need to pay an annual access fee of XXX for ongoing equipment maintenance costs

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What Who How Why

Microbiology

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WhoFor all research staff / students with current and approved GM risk assessments.

How

Researchers contact the genetic modification safety officer to be granted lab access.

Researchers will need to have completed a genetic modification risk assessment, or had an existing authorised project, to be approved.

Researchers will receive an induction, including facility use conditions and waste management procedures before full access is granted.

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LEVEL 4

Researchers will need to pay an annual access fee of XXX for ongoing equipment maintenance costs

Microbiology

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An isolated area for microbiological cultures to protect work in other areas of the buildingEnables user access to be controlled in order to comply with genetic modification safety legislationA shared resource, where researchers can interact and share best practiceShared equipment optimises its use and reduces duplication

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Researchers will need to pay an annual access fee of XXX for ongoing equipment maintenance costs

WhatWe have a new equipment-booking and cost-recovery system in place to use our resources in the most efficient way. Infinity X allows research groups to list items of equipment that they wish to make available to other users. Researchers will be able to search the list of available shared equipment via the software platform with costs displayed, typically as per hour usage charge.

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WhoFor all research staff / students, core facility managers and technical services staff.

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Costs will be displayed in the booking process

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Lee Stanyer

Shared equipment

shared lab facilities

What Who How Why

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Why

A standardised equipment booking and cost-recovery platformOptimises equipment use, by reducing duplication, saving money and spaceSee at-a-glance what equipment is availableGenerates funds to ensure equipment is well maintained, repaired promptly and eventually replaced

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How

Researchers create an Infinity X account using single-sign-on (with their UCL credentials), which is verified by the departmental administrator.

Researchers can book and access shared equipment using the software.

If the item is chargeable, funds will be automatically transferred between account codes, with income used for ongoing maintenance, repair and replacement costs.

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Costs will be displayed in the booking process

WhatWe have 12 shared-use tissue culture laboratories available throughout the building for work with primary cultures, cell lines, stem cell cultures and genetically-modified organismsResearchers will have a tissue culture lab close to their primary workspace, but will have access to all tissue labs across the centre. All labs will operate with the same rules and operate to the same high standards.Typically, each facility will have three microbiological safety cabinets, four to six CO2 incubators, refrigerated centrifuge, microscope and camera, dry water baths, electroporator, cell counter, fridge, freezer and miscellaneous benchtop equipment. These facilities are complemented by the HiPSC core facility, quarantine and quality control facilities and the cryogenic storage facility, on Level B1.

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Tissue culture

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How

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Researchers will receive an induction, and training in aseptic technique before full access is granted.

Safety cabinets will be bookable via Infinity X software. Researchers create an Infinity X account using single-sign-on (with their UCL credentials), which is verified by the departmental administrator).

Users will need to submit media samples of active cultures on a fortnightly basis to assess mycoplasma contamination status.

Researchers contact the genetic modification safety officer to be granted lab access.

ABOUT THE CENTRE

Safety cabinets will be bookable via Infinity X software. Researchers create an Infinity X account using single-sign-on (with their UCL credentials), which is verified by the departmental administrator).

Users will need to submit media samples of active cultures on a fortnightly basis to assess mycoplasma contamination status.

Tissue culture

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Cost

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Fully-equipped facilities with statutory testing, maintenance, repairs and gas replenishmentStandardised methods of operation and consistent induction and training procedures ensure best practice the highest standards of cleanlinessRoutine contamination testing and separation of techniques to minimise cell purity issues

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tissue culture

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WhatThe molecular biology laboratory is a shared-use facility for techniques that require a semi-sterile environment and which need to be isolated from general laboratory procedures to avoid environmental contamination. Following best laboratory practices including aseptic technique, mandatory PPE and decontamination protocols, the lab will cover a range of techniques including, for example, working with RNA.

Molecular biology

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No cost to research staff – a centrally-provided facility

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Molecular biology

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WhoFor all research staff / students and core facility staff

How

We’ll be engaging with PI’s and other stakeholders on the best use of this space.

The techniques and equipment available in this facility are still to be decided.

An induction procedure will be required in this space, prior to access being granted.

shared lab facilities

Why

A shared resource, where researchers can interact and share best practiceShared equipment optimises its use and reduces duplicationConvenient and hygienic - the entire laboratory can be routinely decontaminated, via the scientific services team, using portable vaporised hydrogen peroxide generators

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No cost to research staff – a centrally-provided facility

What Who How Why

WhatOur refrigeration and freezer facilities on site include:

  • an ultra-low-temperature (ULT) central freezer facility for medium-term storage
  • standalone short-term shared ULT freezer storage on lab floors
  • a centralised cryogenic storage facility for the long-term preservation of sensitive biological materials
  • Lab floor underbench fridges, tall freestanding fridges and laboratory cold rooms.

Cold storage

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Cryogenic storageULT freezer facilitiesCold rooms

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How

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The freezer bank and cryogenic storage facilities will be accessible via building access card, issued after induction at 256 Grays Inn Road.

The facility will be supported by a dedicated freezer bank technician or biorepository manager.

Telemetry systems will be monitored 24/7 by technical team personnel with specific members being notified should any issues occur.

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Cold storage

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Cryogenic storageULT freezer facilitiesCold rooms

WhoAll our freezer facilities can be used by all research staff and students, core facility and central service staff

Freezer and cryogenic storage space will be allocated according to biorepository requirements and existing additional needs. Any surplus storage required will be chargeable.

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Cold storage

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Cryogenic storageULT freezer facilitiesCold rooms

Why

Reducing carbon emissions and energy consumption. The Nordic ULT freezer system is a more energy efficient option compared to traditional ULT freezers (low-energy models) and onsite liquid nitrogen generation will result in highly efficient sample storage dewars, reducing overall consumption and eliminating the need for diesel truck deliveriesMaximum storage for minimum footprint: the Nordic ULT freezer system provides approximately 70% more storage, per unit footprint, than traditional ULT freezers and there is enough capacity to future-proof cryogenic storage requirements for the foreseeable futureCentrally-managed facilities include telemetry monitoring systems and extensive monitoring and alarm reporting functions to ensure safe sample storageConsolidated gas monitoring requirements and emergency air evacuation systems to ensure everyone’s safety

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Our centralised cryogenic storage facility will provide vapour-phase liquid nitrogen storage for the cryopreservation of biological materials. We have six large-capacity cryogenic dewars, each with a maximum storage capacity of 92,300 samples (a total vapour-phase storage capacity of approx 553,800 samples). We have three liquid nitrogen generators, with system telemetry, liquid nitrogen level control, flow monitoring and autorefill functionality. They’ll also provide enough product to support lab floor liquid nitrogen needs, with contracts in place for manual refilling if needed.The facility will also have gas monitoring systems and emergency air evacuation technologies to ensure a safe and comfortable environment for everyone.There will be a separate sample reception area for sample registration, barcoding, tracking and to deal with all sample requests.

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Cold storage

Cost

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Cryogenic storageULT freezer facilitiesCold rooms

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Centrally-provided facilities

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ABOUT THE CENTRE

Our Nordic freezer bank is a bespoke ULT freezer system comprised of large-capacity, modular storage units that are supported by a centralised industrial refrigeration plant. The plant operates with 100% redundancy using approximately 40% less energy than traditional standalone freezers and has a 24/7 telemetry, early-warning monitoring system, with pre-alarms for added assurance. The facility will be suitable for medium-term freezer storage and provide over 60,000 litres of storage capacity (equivalent to 81 x 740 litre freezers). 30% of this will be used for sample storage in a dedicated and centrally-managed biorepository, with space for several million samples, with the rest available for lab medium-term storage needs.Short-term storage will be provided with standalone shared ULT freezers on lab floors. Long-term storage can be arranged off site, at an extra cost.

Cold storage

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Cryogenic storageULT freezer facilitiesCold rooms

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Each laboratory floor contains a medium-sized 4˚C cold room for shared use. This can be used for experimental purposes and bulk storage. The total footprint of these four cold rooms is equivalent to the cold room space currently available to IoN staff in Queen Square House, Wakefield Street and the Cruciform building.

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Cryogenic storageULT freezer facilitiesCold rooms

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Centrally-provided facilities

Further information Sentence about resources to download. Ese nihilsectur, aut etumet.

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WhatScientific vending machines (supply centres) will be available in lab lobbies (as well as Room G02 at Queen Square House.)The vending machines provide researchers with immediate on-site access to high demand lab consumables. Users’ grants will be charged on a weekly basis, only once the item has been vended. There are currently three supply centres available: ThermoFisher Fridge (4°), Promega Helix freezer (–20°), Promega Helix (room temperature)

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TBC

Further information New users should contact their Departmental Administrator or Kully Sunner to be set up on the system. DOWNLOAD key documents (to be supplied)

Sergey Novoselov, Dept of Neuromuscular Diseases Mark Gaskin, Clinical and Movement Neurosciences Charlotte Spicer, Dept of Neuromuscular Diseases Kully Sunner, Dept of Neuromuscular Diseases

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Research staff are issued with a card, associated with the grant to be charged, which is swiped to open the supply centre door.

Researchers select the items they want, scan and take their items back to the lab.

Every department has a nominated person, who is responsible for ensuring admin is up-to-date, including raising purchase orders (PO) and updating ThermoFisher and Promega systems.

When the weekly shipments arrive, the Lab Manager responsible will re-stock the supply centre and monitor stock.

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Sergey Novoselov, Dept of Neuromuscular Diseases Mark Gaskin, Clinical and Movement Neurosciences Charlotte Spicer, Dept of Neuromuscular Diseases Kully Sunner, Dept of Neuromuscular Diseases

Further information New users should contact their Departmental Administrator or Kully Sunner to be set up on the system. DOWNLOAD key documents (to be supplied)

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Immediate on-demand access to lab consumables, with ability to customise stock listA weekly consolidated shipment cuts down on deliveries and packagingLess waste, as researchers only order and use what they needStorage in central energy-efficient fridges saves space on lab floors

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Sergey Novoselov, Dept of Neuromuscular Diseases Mark Gaskin, Clinical and Movement Neurosciences Charlotte Spicer, Dept of Neuromuscular Diseases Kully Sunner, Dept of Neuromuscular Diseases

Further information New users should contact their Departmental Administrator or Kully Sunner to be set up on the system. DOWNLOAD key documents (to be supplied)

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ToiletsToilets are located on all lab floors, close to the staircase, in outpatients and MRI areas, and in the Alexandra wing. In addition, there are public toilets on ground floor level, including fully accessible toilets, a changing places facility and a baby-changing unit. All toilets are currently designated as unisex facilities.Changing facilities and showersThere are two large changing rooms on the ground floor– one male and one female, for use by both UCL and UCLH staff. Each has shower cubicles, sinks, heated towel rails and changing-room-style lockers. These lockers are for day-use only and will be on a first-come, first-served basis and should not be for long-term use. Cycling facilitiesWe have approx 100 cycle racks for staff and visitors, available on site, including both covered and cycle hoop options. Cycle storage is located behind the main building, towards the entrance on Cubitt Street, which will be patrolled by UCL security during the day and closed to the public from dusk.

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Quiet room There is a quiet room available for use by UCL staff.Maternity room Available for use by UCL staff for breastfeeding and expressing. SecurityThe main entrance from Grays Inn Road will be staffed by UCL security 24 hours a day, 7 days a week and staff can access the building, as agreed with line managers AccessStaff: UCL staff can access Lab Floors 1–4 along with basement level core facilities with their UCL staff ID card. UCLH staff can access outpatient and MRI rooms with their UCLH staff ID card. All staff will need to complete a building induction before access cards can be issued. Further details will be provided.Patients: Patients visiting the facility will need to check in at the outpatients or MRI receptions ahead of their appointments. Opening hours are to be confirmed Public: The ground floor cafe, toilets and outside areas are open for staff, visitors, patients and the public to enjoy. Opening hours are to be confirmed. During daylight hours, there is public access through the site to Langton Close and St Andrew’s Garden.

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ParkingThere is no standard parking available on site, in line with UCL’s environmental policy and BREEAM certification. On-street car parking is available nearby (£5.50 p/h Mon – Fri 08.30–18.30, Sat 08.30–13.30) but is limited. See parkopedia for parking options nearby. Nearby car parks: NCP, Brunswick Square and NCP, Judd StreetDisabled parkingThere will be two disabled parking bays available on-site, for use by patients to the rear of the site.Ambulance Drop OffThere is an ambulance drop off bay to the rear of the Alexandra Wing.

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ParkingInformation to follow.DeliveriesInformation to follow.PorteringInformation to follow.Cleaning and wasteInformation to follow.

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We have a café, open to all staff, patients and visitors, seating approximately 60 people. It will provide take-away and eat-in food and drink options.When the cafe is closed, vending machines stocking a range of items will be available.

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Our sensory garden area, which sits between the Alexandra Wing and the main centre provides a calm space for staff, patients and visitors away from Grays Inn Road. The garden is designed with accessibility in mind and aims to stimulate senses and provide a peaceful, waiting space. We also have a range of green spaces that are open to the public and landscaped. We also have a range of green spaces that are open to the public and landscaped areas that include bench seating

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Annie Cattrell, Lead public artistAnnie has been commissioned to make a series of major public artworks for 256 Grays Inn Road: Everything is Connected A highly visible sculptural artwork, set on the corner of the new building, gilded in 24-carat gold, and based on ideas of dendritic growth formations and seismic change, inspired by the magnitude of the neurological research and clinical treatments that will take place in the centre.

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UCL Public Art’s programme of arts activities has been designed especially for the IoN-DRI programme

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Mirror A sculptural bas-relief on the archway ceiling of the main entrance from Grays Inn Road, to reflect the importance and significance of the centre, based on ideas of care, skill and interconnectedness. Wise Words Researchers, scientists, clinicians and staff working across the project responded to a questionnaire that Annie circulated. Their thoughts, hopes and expectations, for the new centre, will be reflected in a series of quotes that will be positioned on the walls around the staff areas.

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Left: Everything is ConnectedRight: Mirror (concepts) Annie Cattrell

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Freya Gabie, Artist in Residence Freya has been commissioned to explore the unique history of the site itself and its significance as a hospital, creating an archive of research as well as public artworks. Laertes Atlas Celebrating scientific discoveries of the past alongside today’s ground-breaking research, 12 stained-glass drawings will be lit, using the light of a day in 12 places across the globe, around 12 months of the year, which change on each encounter. The piece is inspired by the 1739 star atlas by Dr John Bevis, who found the historic, health-giving wells beneath the site.

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Left: Uranographia Britannica, John Bevis, c.1750Right: Drawing for ‘Laertes’ Atlas’ on stained glass Freya Gabie

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Furtive Ground Using magnetite and calcium – both compounds found in our brains and in excavated material from site, two clods of earth will be cast in chalk (calcium carbonate) from 35m below the site, and magnetite. Suspended through the building, the magnetite clod will become a compass, and always find magnetic north. DownstreamA collaboration with the British Library’s ‘Water Library’ and co-created with a neurologist and AI developer, Downstream is a participatory, unfolding sound work for the MRI suite, inviting people to take a journey through other people’s memories of sound, accumulating as a collective woven river of sound.

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Furtive Ground: archaeological core sample of Lambeth Red and site manager John Mitchell with clod sample. Freya Gabie

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Trellis: Arbor Art Programme A knowledge-exchange programme for staff and researchers of the Queen Square Institute of Neurology, artists and communities

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Left: Everything is Connected Right: Mirror (concepts) Annie Cattrell

Walking in your Footsteps A collaborative project between Dr Natalie Ryan, artist Briony Campbell and members of the Rare Dementia Support Familial Alzheimer’s disease support group to develop creative collage workshops where people can connect and share their stories and experiences. Ebb & Flow Neuroscientists Dr Tatiana Alvarez Giovannucci and Mar Estarellas and artist Lucy Steggals connect artists, scientists and people with lived experience of dementia and their carers together to share experiences of uncertainty, using the metaphor of the sea.

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Drawing the Stuff of Memory Neuroscientist Dr Kirsty Lu and artist Maria Teresa Ortoleva take a compassionate look at the lived experience and fear of memory loss, exploring the phenomenon of memory and how it is perceived, through drawing. How to Swim on Land Researcher Louie Lee and artist Caroline Wright explore the unique relationship that people living with neuromuscular diseases have with water. I Hear You: a Soundscape of the Unheard World of Parkinson’sNeuropsychologist Dr Jennifer Foley and artist Alison Carlier explore the unheard voices of younger people affected by Parkinson’s, combining stories, sounds of rhythmical motor symptoms with ambient sound and music, to build a textured soundscape of what it feels like to live with the disease. In Search of Lost Time Clinician scientist Dr Tom Miller and artist Lynn Dennison look at memory loss in patients to give a voice to patients with LG11-limbic encephalitis to describe and capture the first-person experiences of amnesia using storytelling, moving image, audio and photography.

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Left: Everything is Connected Right: Mirror (concepts) Annie Cattrell

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We have a lecture theatre on the ground floor, seating up to 200 people, which can be used for lectures, events or larger meetings. It can be set up both as a theatre, with raked seating, or ‘cabaret style’ with tables. The theatre is fitted with a hearing induction loop, as well as seating and access for wheelchair users

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Our building is next door to the Calthorpe Community Garden – a community garden and green space, which offers a range of activities, from gardening to sports from fitness to wellbeing and creative projects and programmes. Our neighbours also include residents of Calthorpe Estate to the rear and Trinity Court on Grays Inn Road; students in UCL self-catering accommodation Frances Gardener House and Langton Close behind, as well as St Andrew’s Garden – a small park and green space. During daylight hours, there is public access through the site to Langton Close and St Andrew’s Garden.

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The National Hospital for Neurology and Neurosurgery (part of University College London Hospitals NHS Foundation Trust) has an outpatient department on the ground floor with 21 clinic rooms, phlebotomy and a pharmacy. The facilities will improve patient access, as well as opening up more opportunities for patients to learn about, and take part in, research through a Patient Research Hub. The centre’s approach builds upon close working relationships between UCL and the NHNN in neuroscience by bringing together scientists, clinicians, patients and families under one roof.

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MRI suiteThere is a shared UCL and UCLH MRI suite in the basement of the building, providing additional capacity for National Hospital for Neurology and Neurosurgery patients, as well as imaging for research. There are five, high performance, MRI scanners in the new centre.

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Information on visiting the centre, including maps and how to get here to follow

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This page is in development. More information to come

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Ask us anything. Send us your questions, feedback and suggestions and read our frequently asked questions here.

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If you would like to share your views or ask a question, we would really like to hear from you. Get in touch

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UCL Queen Square Institute of Neurology

UK Dementia Research Institute

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