Pharmacokinetics
Medical uses
The principle pharmacological action of GTN is the relaxation of vascular smooth muscle. GTN produces, in a dose related manner, dilation of both arterial and venous beds
GTN works by widening blood vessel. This increases the blood supply to the heart, which gets more oxygen to the heart muscle in result reducing angina
Action of GTN
Indication & contra-indication
Glyceryl trinitrate GTN
A vasodilator that results in:
- Dilation of coronary arteries
- Dialtion of systemic veins
- Reduced blood pressure
Administer GTN to any patient who has cardiac chest pain due to angina. Also, to a patient who has an acute cardiogenic pulmonary edema.
What is GTN?
Medically, GTN is a vasodilator that eases chest pain. Also, GTN is an important ingredient in dynamite and other explosives (TNT). Ascanio Sobrero a chemist that first discovered GTN in 1846. However he delayed revealing his discovery because of its explosive action.
Conclusion
Desired effect & side effects
GTN stands as a multifaceted compound with a rich history, serving both as a lifesaving medication for heart patients and a powerful tool in various explosive applications.
The purpose of GTN is to treat the symptoms of angina. However, there are side effects that come along with taking GTN including...
Chemical Structure & composition
References
“(1) Common Questions about Glyceryl Trinitrate (GTN).” Nhs.uk, 12 Apr. 2023, www.nhs.uk/medicines/glyceryl-trinitrate-gtn/common-questions-about-glyceryl-trinitrate-gtn/.(2) Ferreira, Julio C.B., and Daria Mochly-Rosen. “Nitroglycerin Use in Myocardial Infarction Patients: Risks and Benefits.” Circulation Journal : Official Journal of the Japanese Circulation Society, vol. 76, no. 1, 2012, pp. 15–21, (3) Glyceryl Trinitrate (GTN). 25 Apr. 2019.(4) Pearson, Russell, and Anthony Butler. “Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance.” Molecules, vol. 26, no. 21, 30 Oct. 2021, p. 6581, www.ncbi.nlm.nih.gov/pmc/articles/PMC8587134/#, https://doi.org/10.3390/molecules26216581. Accessed 1 Feb. 2022.(5) “Nitroglycerin | Chemical Compound | Britannica.” Encyclopædia Britannica, 2019, www.britannica.com/science/nitroglycerin.(6)PubChem. “Nitroglycerin.” Nih.gov, PubChem, 2019, pubchem.ncbi.nlm.nih.gov/compound/Nitroglycerin.
C3H5N3O9, Nitroglycerin is a nitroglycerol that is glycerol with nitro groups replacing the hydrogen atoms of all three hydroxy groups.
- Angina is chest pain that happens when not enough blood gets to the muscles of the heart.
- By widening blood vessels GTN makes it easier for your heart to pump blood around your body, so your heart muscles get more oxygen. Reducing the risk of getting angina
- Headache
- Dizziness
- Hypotension
Adminster GTN to any patient with chest pain due to angina, MI, or acute cardiogenic pulmonary oedema. However DO NOT administer GTN to a patient with:
- Hypotension (SP < 90mmHg)
- Hypovolemia
- Head trauma
- Cerebral hemorrhage
- Unconscious patient
- If Sildenafil (Viagra) and other related drugs have been taken in the pervious 24 hours.
When GTN is taken it is then converted in the smooth muscle cells in the blood vessels to nitric oxide, which enhances the activation of cyclic GMP (Downstream effect e.g. vasodilation) in turn results in smooth muscle relaxation.
GTN
Mariam Alnaqbi
Created on October 23, 2023
This is an interactive poster presentation that talks about glyceryl trinitrate in pre-hospital use and has some general background information
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Transcript
Pharmacokinetics
Medical uses
The principle pharmacological action of GTN is the relaxation of vascular smooth muscle. GTN produces, in a dose related manner, dilation of both arterial and venous beds
GTN works by widening blood vessel. This increases the blood supply to the heart, which gets more oxygen to the heart muscle in result reducing angina
Action of GTN
Indication & contra-indication
Glyceryl trinitrate GTN
A vasodilator that results in:
Administer GTN to any patient who has cardiac chest pain due to angina. Also, to a patient who has an acute cardiogenic pulmonary edema.
What is GTN?
Medically, GTN is a vasodilator that eases chest pain. Also, GTN is an important ingredient in dynamite and other explosives (TNT). Ascanio Sobrero a chemist that first discovered GTN in 1846. However he delayed revealing his discovery because of its explosive action.
Conclusion
Desired effect & side effects
GTN stands as a multifaceted compound with a rich history, serving both as a lifesaving medication for heart patients and a powerful tool in various explosive applications.
The purpose of GTN is to treat the symptoms of angina. However, there are side effects that come along with taking GTN including...
Chemical Structure & composition
References
“(1) Common Questions about Glyceryl Trinitrate (GTN).” Nhs.uk, 12 Apr. 2023, www.nhs.uk/medicines/glyceryl-trinitrate-gtn/common-questions-about-glyceryl-trinitrate-gtn/.(2) Ferreira, Julio C.B., and Daria Mochly-Rosen. “Nitroglycerin Use in Myocardial Infarction Patients: Risks and Benefits.” Circulation Journal : Official Journal of the Japanese Circulation Society, vol. 76, no. 1, 2012, pp. 15–21, (3) Glyceryl Trinitrate (GTN). 25 Apr. 2019.(4) Pearson, Russell, and Anthony Butler. “Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance.” Molecules, vol. 26, no. 21, 30 Oct. 2021, p. 6581, www.ncbi.nlm.nih.gov/pmc/articles/PMC8587134/#, https://doi.org/10.3390/molecules26216581. Accessed 1 Feb. 2022.(5) “Nitroglycerin | Chemical Compound | Britannica.” Encyclopædia Britannica, 2019, www.britannica.com/science/nitroglycerin.(6)PubChem. “Nitroglycerin.” Nih.gov, PubChem, 2019, pubchem.ncbi.nlm.nih.gov/compound/Nitroglycerin.
C3H5N3O9, Nitroglycerin is a nitroglycerol that is glycerol with nitro groups replacing the hydrogen atoms of all three hydroxy groups.
Adminster GTN to any patient with chest pain due to angina, MI, or acute cardiogenic pulmonary oedema. However DO NOT administer GTN to a patient with:
When GTN is taken it is then converted in the smooth muscle cells in the blood vessels to nitric oxide, which enhances the activation of cyclic GMP (Downstream effect e.g. vasodilation) in turn results in smooth muscle relaxation.