WG2_meeting_May 23

Working group 2

Pharmacological regulation and drugs

01. RELEVANT info

From the MC meeting hosted at Zagreb

• Training schools (Bratislava, dates 26-30/06/2023).
• Next Scientific+MC meetings (Graz, dates 12-14/10/2023).
• Grant awarding Commitee: 8 STSMs; 1 VM; 10 ITC and 8 DCG.
• Remember that all members should be inscribed in a WG.

• Sci articles publication in OA: 3 different countries.

02. Mou included tasks

2.1) Inventory of drugs suitable for repurposing as NRF2-based therapeutics.2.2) Inventory of new patented or patentable compounds that activate or inhibit NRF2 and influence the course of various NCDs in cellular and animal models of disease, including electrophiles, PPI inhibitors and NRF2 inhibitors developed by the Action participants.2.3) Coordinate a virtual repository of superior animal models for various NCDs with pathophysiological processes related to NRF2 deregulation, in reciprocal interaction with “Preclinical Trials. EU” organization.2.4) Critical analysis of preclinical results on the above mentioned NRF2-modulators in superior animal models.

This WG will coordinate all aspects along the pipeline of drug development, including preclinical studies.

03. specific contribution of the members:

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DISEASES MODELS

TOOLS

Activators/ inhibitors

MOLECULAR LEVEL

04. superior animal models for various NCDs with pathophysiological processes related to NRF2 deregulation

This WG will coordinate all aspects along the pipeline of drug development, including preclinical studies.

05. REVIEW to be published elsewhere including bedbedphar special issues:

06. HOW WILL we BE CONNECTED?

Intranet BenBedPhar

Thank you

Let's continue working!!

Albena Dinkova-Kostova

A.DinkovaKostova@dundee.ac.uk

Ana I Rojo

airojo@iib.uam.es