WG2 report Oct 23

Working group 2

Pharmacological regulation and drugs

Summary of the second year activities

October

June

March

April

January

September

Joined activities

STMs

Publications

Dissemination

Grant proposals

Deliverables. Mou included tasks

2.1) Inventory of drugs suitable for repurposing as NRF2-based therapeutics.2.2) Inventory of new patented or patentable compounds that activate or inhibit NRF2 and influence the course of various NCDs in cellular and animal models of disease, including electrophiles, PPI inhibitors and NRF2 inhibitors developed by the Action participants.2.3) Coordinate a virtual repository of superior animal models for various NCDs with pathophysiological processes related to NRF2 deregulation, in reciprocal interaction with “Preclinical Trials. EU” organization.2.4) Critical analysis of preclinical results on the above mentioned NRF2-modulators in superior animal models.

This WG will coordinate all aspects along the pipeline of drug development, including preclinical studies.

D2.1. Inventory of new and repurposed NRF2-targeting drugs.

To create an inventory of repurposed/new NRF2-targeting drugs, which will be included in a future publication and will be listed on the BenBedPhar webpage. Notably, we have done a lot of work summarized the information of NRF2 activators and inhibitors and converting them into a more user-friendly tool to be inserted in the COST action web page, employing Access software (Microsoft 365). This task has been especially driven by Srdjan Bjedov, Albena Dinkova-Kostova and Ana I Rojo.

D2.2. REGISTRY OF SUPERIOR NRF2-RELATED ORGANISM MODELS OF NCDs

We are preparing a comprehensive review manuscript summarizing all animal models of noncommunicable diseases where NRF2 is relevant thanks to the active participation of 23 members of the WG2. This review is authorized by (alphabetic order) Buttari, Cadenas, Carlos, Cuadrado, Dinkova-Kostova, Falcão, G López, Konu, Lastres-Becker, Maksimova, Michaeloudes, Mihaylova, Milisav, Miova, Rojo, Santos, Seabra, Svob, Sykiotis, Trougakos, Tenreiro, Rada and Mike. In this task aim to will include extensive inventory of superior animal models.

Thank you

Let's continue working!!

Albena Dinkova-Kostova

A.DinkovaKostova@dundee.ac.uk

Ana I Rojo

airojo@iib.uam.es

WG2 meeting

40 participants

• We summarized the relevant information from next MC/Sc meeting and traning school. Intranet working flux.
• Hightlighted the main aims of WG2 that should be accomplished during the next 2-3 months.
• We shared the first draft/outline of the planned comprehensive review summarizing all animal models of NCDs where NRF2 is relevant (2nd deliverable)

(https://view.genial.ly/64633bcb4e79c100127ce77f).

Publications aknowledging our COST action

Albena Dinkova-Kostova (University of Dundee) and Andrey Abramov (UCL). Albena Dinkova-Kostova (University of Dundee) and Ian Copple (University of Liverpool). Albena Dinkova-Kostova (University of Dundee) and Milen Georgiev (Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences). Sharadha Dayalan Naidu and Albena Dinkova-Kostova (University of Dundee). Miranda JP

Joined Grants Proposal

1. Alessandra Berry and Brigitta Buttari.
2. Ana I Rojo and Claudia G Almeida.
3. Isabel Lastres-Becker and Ana Martinez.
4. Cagatay Karaaslan and Arie Lev Gruzman.
5. Katja Kanninen, Manuela G López, Andreas Daiber and Antonio Cuadrado.
6. Nesrin Kartal Özer, Erdi Sozen and Ana I Rojo
7. Tugba Boyunegmez Tumer and Anna Grochot-Przeczek.
8. Eugenia Carvalhho.
9. Liliya Mihaylova, Martina Savova and Monika Todorova.

Second deliverable

Review organization

We organized the WG members who were able to participate in contributing to the virtual repository of superior animal models for various NCDs with pathophysiological processes related to NRF2 deregulation

Redox webinar series

NRF2 and neuroinflammation

Many members of WG2, including PhD students and other early career researchers, attended the ‘Redox webinar series. Oxidative Stress: Biochemical and Pharmacological aspects’. Ana I Rojo and Isabel Lastres-Becker were two of the three invited speakers in the “NRF2 and neuroinflammation" webminar. Introduced by Brigitta Buttari and Antonio Cuadrado.

https: Antiox.it

Intranet BenBedPhar

We changed the information related to WG2 from Slack Platform to BenBedPhar intranet.

Information about the structure and content of BenBedPhar, and, most importantly, an overview of the goals and tasks of WG2, as well as deliverables and deadlines.

https://benbedphar.org/

OpenDay 2023

Some of the WG2 members participated as invited speakers in the BenBedPhar Open Day on 7th September (Laureano de la Vega, Gina Manda, Antonio Cuadrado, Andreas Daiber and Sandra Tenreiro). This event was organized by Ana Rita Carlos and Isabel Lastres-Becker. The hybrid nature of this event allowed the attendance of many WG2 members, including PhD students, from multiple institutions across Europe.

4th BenBedPhar meeting

Zagreb

WG2 contributed 19 abstracts and presentations, authored by Albena T. Dinkova-Kostova, Ioannis P. Trougakos, Andrey Y. Abramov, Kattri-Liis Eskla, Marlene E Moreira Santos, Ángela María Martínez Valverde, Katja Kanninen, Isabel Lastres-Becker, Gerasimos Sykiotis, Srđan Bjedov, Ana Sofia Falcão, Silvia Giordani, Antonio Cuadrado, Nesrin Kartal Özer, Santiago Cuevas, Anna-Liisa Levonen, Michel Edwar Mickael, Andreas Daiber, Monika Mlinarić.

Training School 2023

Smolenice Castle, Slovakia

5 members of WG2 participated as invited trainers:Antonio Cuadrado, Manuela G López, Albena Dinkova-Kostova, Ioannis P. Trougakos and Gina Manda

https://benbedphar.org/training-school-nrf2-in-noncommunicable-diseases-from-bench-to-bedside/

5th BenBedPhar meeting

Graz

WG2 contributed 20 abstracts and presentations, authored by Tugba Boyunegmez Tumer, Ana Čipak Gašparović, Ana I. Rojo, Albena T. Dinkova-Kostova, Sibel Kalyoncu Uzunlar, Silvia Giordani, Michel Edwar Mickael, Roberto Motterlini, Roberta Foresti, Đorđe Miljković, Mihaela Matovina, Chakradhara Rao Satyanarayana, Gerasimos P. Sykiotis, Antonio Cuadrado, Brigitta Buttari, Harry van Goor, Fabio Di Domenico, Gulay Sezer, Anton Terasmaa and Erkan Tuncay.

PhD STMs

1. From Lisbon to Dundee 2. From Lisbon to Sweeden 3. From Prague to Lisbon 4. From Madrid to Lisbon 5. From Lisbon to Madrid

Second deliverable

Review deadline

We already finished the sections from the proposed review receiving the authors imput. (Aprox 29th September)

Posters and oral communications

1. ENDO conference (Chicago)
2. Training school (Slovakia)
3. International congress of neurodegenerative diseases (Málaga)
4. 4th International Conference on food bioactives and health (Prague)