Cytopathic Effects (CPEs)
By Abigail Westrum
How can we see them?
What are CPEs?
CPEs can be observed with an inverted light microscope under low magnification.
CPEs are visual changes in the host cell due to viral infection.
Syncytia
Syncytia is the fusion of multiple cells membranes, resulting in giant multinuclear cells. Syncytia is common in Measles, Repsiratory Syncytial Virus (RSV), and HIV.
Common Observations
Causes of CPEs
- Formation of inclusion bodies
- Rounding of cells
- Shrinkage
- Increased refractility
- Syncytia
- Aggregation
- Loss of adherence
- Cell lysis/death
- Entry into host cell
- Inhibition of cellular transcription
- Inhibition of cellular RNA polymerase activity
- Virus interactions with RNA processing pathways
- Virus interaction with ribosomes
- Host responses to viral infection
Source: Teri Shors; Understanding Viruses, Third Edition
Cytopathic Effects
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Created on March 12, 2023
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Transcript
Cytopathic Effects (CPEs)
By Abigail Westrum
How can we see them?
What are CPEs?
CPEs can be observed with an inverted light microscope under low magnification.
CPEs are visual changes in the host cell due to viral infection.
Syncytia
Syncytia is the fusion of multiple cells membranes, resulting in giant multinuclear cells. Syncytia is common in Measles, Repsiratory Syncytial Virus (RSV), and HIV.
Common Observations
Causes of CPEs
Source: Teri Shors; Understanding Viruses, Third Edition