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Cytopathic Effects

abigaillwestrum

Created on March 12, 2023

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Transcript

Cytopathic Effects (CPEs)

By Abigail Westrum

How can we see them?

What are CPEs?

CPEs can be observed with an inverted light microscope under low magnification.

CPEs are visual changes in the host cell due to viral infection.

Syncytia

Syncytia is the fusion of multiple cells membranes, resulting in giant multinuclear cells. Syncytia is common in Measles, Repsiratory Syncytial Virus (RSV), and HIV.

Common Observations

Causes of CPEs

  • Formation of inclusion bodies
  • Rounding of cells
  • Shrinkage
  • Increased refractility
  • Syncytia
  • Aggregation
  • Loss of adherence
  • Cell lysis/death
  • Entry into host cell
  • Inhibition of cellular transcription
  • Inhibition of cellular RNA polymerase activity
  • Virus interactions with RNA processing pathways
  • Virus interaction with ribosomes
  • Host responses to viral infection

Source: Teri Shors; Understanding Viruses, Third Edition