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Aging Research History

John-David Butler

Created on February 23, 2023

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Transcript

History of Aging Research

A brief overview of the significant discoveries in human aging research.

START

What exactly is aging?

  • Many different defintions.
  • My favorites:
    • Time-dependent physiological decline
    • Slow deterioration of physiological function
    • Aging can be defined as the time-related deterioration of the physiological functions necessary for survival and fertility (Aging: The Biology of Sensecene.)

Why does it matter?

  • Aging is bad.
    • Aging is the leading risk factor for the leading causes of death in adults worldwide.
      • cancer
      • heart disease
  • Who wants to get old???
    • Matintain quality of life!
    • Continue doing things we enjoy!
      • running, hiking, playing sports, playing with your kids.
  • Not about immortality!

Significant discoveries in aging research*Not an exhaustive list*

  • 1935 - Caloric Restriction
  • 1983 - Telomeres
  • 1984 - Telomerase
  • 1982 - Daf2 gene
  • 2009 - Drugs!
  • 2013 - Hallmarks of aging
  • 20? - Levine, Horvath - Methylation
  • 2023 - Epigenetics

Significant discoveries in aging research*Not an exhaustive list*

  • 1935 - Caloric Restriction
  • 1983 - Telomeres
  • 1984 - Telomerase
  • 1982 - Daf2 gene
  • 2009 - Drugs!
  • 2013 - Hallmarks of aging
  • 20? - Levine, Horvath - Methylation
  • 2023 - Epigenetics

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