cream presentation

Pharmaceutics 3 Practical

presentationabout creams

W/O emulsion typeW/O emulsion type The external layer is oil.W/O emulsion type The external layer is oil.The external layer is oil.

dr. Amani Alshalakhtistudent: .wesam al odat .taha hamdan

creams

Definition:

• Viscous (sticky) • Homogenous • Used externally (skin and mucus membranes) • Relatively high fluid consistency • Are O/W or W/O emulsion • API dissolved or dispersed in base • Hydrophilic or hydrophobic base • Miscible with skin secretion • Suitable for vaginal application

Uses for creams:

1. Protective effect 2. Therapeutic effect 3. Prophylactic purpose 4. treatment for -eczema, anti itching and emollient for skin

creams

Pharmaceutical creams are classified as water-removable bases in the USP and are described under Ointments Classification according to: 1 ) Function: cleansing, foundation, massage, etc 2 )Characteristics properties: cold creams, vanishing creams, etc. 3 ) Others: All-purpose cream and general creams. Night cream and massage creams. Skin protective cream Hand and body creams. Semisolid Pharmaceutical

type of creams:

3 - CLEANSING CREAM

1- Nature/type of emulsion:w/o or o/w

2- COLD CREAM

5 - FOUNDATION CREAM

4 - VANISHING CREAM

- MOISTURIZING CREAM

1- Nature/type of emulsion:

1- o/w emulsion type creams Vanishing creams Foundation creams. 2- w/o emulsion type creams Cleansing cream, Cleansing milk, Cleansing lotion Cold cream =Moisturizing creams =Winter cream

2- COLD CREAM

types: 1- W/O emulsion cream, when applied to skin, a cooling effect is produced due to slow evaporation of water present in the emulsion. 2- O/W emulsion, when applied to skin, sufficient water evaporates to permit phase inversion to w/o emulsion.

3- CLEANSING CREAM

types: 1. Liquefying cleansing cream 2. Emulsified creams of o/w type 3. Emulsified creams of w/o typ Uses: 1. To remove facial makeup 2. To improve the healthy/good appearance of the skin 3. To remove grime, sebum & other secretion, dead cells and applied makeup. -Pepsin is added to make the facial skin smooth

4- VANISHING CREAM

• Spread easily • o/w emulsion type • When applied to the skin leave an almost invisible layer on it so-called vanishing creams. • Can be quickly washed off with water since its O/W emulsion

5- FOUNDATION CREAM

• Mostly O/W emulsion • To provide a smooth emollient base for the application of facial makeup. • Act as skin protectives to prevent the damage caused by environmental factors like sun, wind, dirt, etc

6- MOISTURIZING CREAM

• Designed to be left on the skin. • An occlusive layer slows the rate of transepidermal water loss • Having a moisturizing effect • Prevent the dry condition of the skin

CREAM

The Cream base should: • Not produce irritation or sensitization of the skin, • Not retard wound healing; • Smooth, inert, odorless or almost odorless, • Physically and chemically stable and compatible with the skin and API Preservatives: Creams contain suitable antimicrobial preservatives unless the API or bases themselves have sufficient bactericidal or fungicidal activity. Creams may contain other suitable auxiliary substances such as antioxidants, stabilizers, thickeners and emulsifiers.

Vanishing cream

Cold cream

-Spermaceti 125gm.-Oily phase-White beeswax (emulsifying agent) 120gm. -Liquid paraffin 560gm. -Aqueous phase -Sodium borate (emulsifying agent) 5gm. -Purified water 190gm.

-Stearic acid (emulsifying agent) 15gm. -Oily phase -White beeswax 2gm. -White soft paraffin 8gm. -Aqueous phase -Triethanolamine 1.5gm. -Propylene glycol 8gm. -Purified water 655gm.

VS

Vanishing cream

Cold cream

W/O emulsion typeW/O emulsion type The external layer is oil.W/O emulsion type The external layer is oil.The external layer is oil.

-W/O emulsion typeThe external layer is oil. -At the night time. - It shines and does not vanish from skin, and the particles remain on skin. -No moisturizing agent is added - The aqueous layer is glyceryl beeswax -5-80% oil of its weight.

-O/W emulsion type The external layer is water. - At the day tim - It vanishes quickly from the skin and does not form a layer on the skin Moisturizing agents is addedfrom the other particles. - The aqueous layer is alkaline in nature. -15-25% oil of its weight.

VS

CREAMS Pharmaceutical Cream can be either: • Water in oil (w/o) emulsion • Oil in water (o/w) emulsion Consisting of: 1. Oily phase contains waxes, emollients and lubricants 2. Water phase contains emulsifying, stabilizing and thickening agents, preservatives and in some cases, colorant. 3. API are: 1.Dispersed in either phase, or 2.Added when the emulsion has been formed and allowed to cool.

Method of preparation:

-Weigh the required amount of spermaceti, beez wax, and mineral oil, and melt them in a water bath ranging (70 -75°c). -Dissolve the sodium borate in purified water, then add it to the first prepared mixture, and mix them well, after that adds the remains of water, until it becomes homogenous cream. .-Stir the cream until it becomes col

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MANUFACTURING PROCESS

1. Preparation of oily phase : 1. Powder ingredients dry blended 2. Then powder mixture is dispersed into mineral oil or silicone oil. (Heating may be required to melt some ingredients) 2. Hydration of aqueous phase ingredients : Emulsifiers, thickeners and stabilizers are dispersed into water in a separate vessel. Heating may be required to accelerate hydration. 3. Formation of emulsion The two phases are blended under vigorous agitation to form the emulsion 4. Dispersion of the active ingredients: API makes up only a small proportion of the formulation; API must be efficiently dispersed to maximize product effectiveness.

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PACKAGING

In well-closed containers with closures that minimize contamination with micro-organisms collapsible tubes of suitable metal or plastic. 6. Labelling: 1. The cream is sterile, 2. The name and concentration of any added antimicrobial preservative 3. The storage conditions; Store at temperatures below 25 unless otherwise directed. ℃ Do not freeze.

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CREAM EVALUATION

1. Uniformity of weight 2. Sterility (For Sterile cream) 3. Irritancy study 4. Determination of pH 5. Physical appearance 6. Spreadability 7. Saponification value & Acid value (If oily base is used) 8. Viscosity 9. Homogeneit

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