Regulasi Ekspresi Gen

Mata Kuliah Biomolekuler dan Biokimia Fisioterapi

Regulasi Ekspresi Gen

Tim Dosen Pengampu MK Biomolekuler dan Biokimia Fisioterapi

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SUB CAPAIAN PEMBELAJARAN MATA KULIAH

Setelah menyelesaikan pertemuan kuliah ini, mahasiswa mampu menjelaskan regulasi/kontrol ekspresi gen

regulasi

REGULASI EKSPRESI GEN

Nukleus

Sitosol

inactive mRNA

5 Kontrol degradasi mRNA

1 Chromatin Remodelling

mRNA

mRNA

DNA

Transkrip RNA

4 Kontrol transpor dan lokalisasi RNA

3 kontrol pemrosesan RNA

6 Kontrol Translasi

2 kontrol transkripsi

Inactive protein

Protein

7 kontrol aktivitas protein

Active protein

regulasi

chromatin remodelling

Chromosomes are composed of DNA and associated proteins, together called chromatin

chromatin remodelling

https://courses.lumenlearning.com/wm-biology1/chapter/reading-eukaryotic-epigenetic-gene-regulation/

chromatin remodelling

QUESTION

In general, what are the effects of histone acetylation and DNA methylation on gene expression?

https://courses.lumenlearning.com/wm-biology1/chapter/reading-eukaryotic-epigenetic-gene-regulation/

kontrol transkripsi

Kontrol Transkripsi

kontrol transkripsi

General Transcripstion Factor + RNA Polymerase II --> Low rates of initiation

Enhancer + Specidic Transcription Factors (Activator or Repressor) the rate of gene expression can be strongly increased or decreased by the binding of specific transcription factors, either activators or repressors, to the control elements of enhancers

pemrosesan rna

Kontrol Pemrosesan mRNA

transpor & lokalisasi rna

TRANSPOR DAN LOKALISASI RNA

kontrol translasi

Kontrol Translasi

Lokalisasi mRNA sitoplasmik

Inisiasi Translasi

The information that governs the cytoplasmic localization of these mRNAs resides in the 3 ′ UTR

Kontrol stabilitas mRNA

Nucleotide sequences that affect how long an mRNA remains intact are often found in the untranslated region at the 3′ end of the molecule

The longevity of an mRNA is related to the length of its poly(A) tail.

degradasi mrna

kontrol aktivitas protein

Kontrol Aktivitas Protein

Finally, the length of time each protein functions in the cell is strictly regulated by selective degradation.

To mark a protein for destruction, the cell commonly attaches molecules of a small protein called ubiquitin to the protein. Giant protein complexes called proteasomes then recognize the ubiquitin tagged proteins and degrade them.

Thanks for your attention

Any questions?