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Transfection

Àngel Térmens Forcada

Created on June 12, 2022

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Transcript

Cell transfection

By: Àngel Térmens Forcada

Start

Index

Introduction

Deliveries

Transfection types

Transfection methods

Reagents

Conclusion

01

Introduction to cell transfection

What is transfection?

Transfection is the process of introducing nucleic acids into eukaryotic cells by non viral methods.

How does transfection work?

Using various chemical or physical methods, this gene transfer technology enables the study of gene function and protein expression in a cellular environment.

Transfection applications

...as one of the earliest study steps...

01

02

03

mammalian promoter and enhancer sequences studies
trans-acting proteins studies
mRNA processing

Transfection applications

...as one of the earliest study steps...

05

06

04

protein-protein interactions
translation studies
recombination events

02

Deliveries

DNA

Transcient and stable

RNA

Transcient

03

Transfection types

Transfection types

Stable transfection

Transient transfection

Cotransfection

Stable transfection

Transcient transfection

Cotransfection

04

Transfection methods

Transfection methods

Calcium phosphate transfection

RNAi & siRNA Transfection

Cationic lipid transfection

Transfection methods

CRISPR transfection

Electroporation

In vivo transfection

05

Reagents

Reagents for continuous cell lines

Neon electroporation

Lipofectamine 2000

Lipofectamine 3000

Lipofectamine LTX

Lipofectamine RNAiMAX

Lipofectamine CRISPRMAX

Invivofectamine 3.0

Reagents for primary and stem cells

Neon electroporation

Lipofectamine 3000

Lipofectamine Stem

Lipofectamine LTX

Lipofectamine RNAiMAX

Lipofectamine CRISPRMAX

Lipofectamine MessengerMAX

06

Conclusion

Conclusion

The choice between transient or stable transfection will usually depend on your goals, cell type and the facilities available to you. In short, transient transfection exerts a temporary influence on your cells, whereas stable transfection leads to permanent genetic changes that are usually passed on to future cell progeny.

Webgraphy

ThermoFisher scientist

Altogen Biosystems

Promega

Lonza

Thanks!