Most cited COVID-19 studies by San Diego researchers
A look at San Diego's impact on coronavirus research during the pandemic.
Title: The proximal origin of SARS-CoV-2 Authors: Andersen, KG (Andersen, Kristian G. Andersen, Andrew Rambaut, W. Ian Lipkin, Edward C. Holmes, Robert F. Garry Times cited: 1,372
Abstract: "SARS-CoV-2 is the seventh coronavirus known to infect humans; SARS-CoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus."
Title: Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2 Authors: Xingguang Li, Junjie Zai, Qiang Zhao, Qing Nie, Yi Li, Brian T. Foley, Antoine Chaillon Times cited: 791
Abstract: "To investigate the evolutionary history of the recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China, a total of 70 genomes of virus strains from China and elsewhere with sampling dates between 24 December 2019 and 3 February 2020 were analyzed. To explore the potential intermediate animal host of the SARS-CoV-2 virus, we reanalyzed virome data sets from pangolins and representative SARS-related coronaviruses isolates from bats, with particular attention paid to the spike glycoprotein gene. We performed phylogenetic, split network, transmission network, likelihood-mapping, and comparative analyses of the genomes."
Title: Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals Authors: Alba Grifoni, Daniela Weiskopf, Sydney Ramirez, Jose Mateus, Jennifer M. Dan, Carolyn Rydyznski Moderbacher), Stephen A. Rawlings, Aaron Sutherland, Lakshmanane Premkumar, Ramesh S. Jadi, Daniel Marrama, Aravinda M. de Silva, April Frazier, Aaron F. Carlin, Jason A. Greenbaum, Bjoern Peters, Florian Krammer, Davey M. Smith, Shane Crotty, Alessandro Sette Times cited: 783
Abstract: "Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic control measures. Using HLA class I and II predicted peptide 'megapools,' circulating SARS-CoV-2-specific CD8(+) and CD4(+) T cells were identified in similar to 70% and 100% of COVID-19 convalescent patients, respectively."
Title: A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV Authors: Meng Yuan, Nicholas C. Wu, Xueyong Zhu, Chang-Chun D. Lee, Ray T. Y. So, Huibin Lv, Chris K. P. Mok, Ian A. Wilson Times cited: 400
Abstract: "The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has now become a pandemic, but there is currently very little understanding of the antigenicity of the virus. We therefore determined the crystal structure of CR3022, a neutralizing antibody previously isolated from a convalescent SARS patient, in complex with the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) protein at 3.1-angstrom resolution ... These results provide molecular insights into antibody recognition of SARS-CoV-2."
Title: Prevalence of Asymptomatic SARS-CoV-2 Infection A Narrative Review Authors: Daniel P. Oran, Eric J. Topol Times cited: 395
Abstract: "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly throughout the world since the first cases of coronavirus disease 2019 (COVID-19) were observed in December 2019 in Wuhan, China. It has been suspected that infected persons who remain asymptomatic play a significant role in the ongoing pandemic, but their relative number and effect have been uncertain. The authors sought to review and synthesize the available evidence on asymptomatic SARS-CoV-2 infection."
Most cited COVID-19 studies by SD researchers
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Most cited COVID-19 studies by San Diego researchers
A look at San Diego's impact on coronavirus research during the pandemic.
Title: The proximal origin of SARS-CoV-2 Authors: Andersen, KG (Andersen, Kristian G. Andersen, Andrew Rambaut, W. Ian Lipkin, Edward C. Holmes, Robert F. Garry Times cited: 1,372
Abstract: "SARS-CoV-2 is the seventh coronavirus known to infect humans; SARS-CoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus."
Title: Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2 Authors: Xingguang Li, Junjie Zai, Qiang Zhao, Qing Nie, Yi Li, Brian T. Foley, Antoine Chaillon Times cited: 791
Abstract: "To investigate the evolutionary history of the recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China, a total of 70 genomes of virus strains from China and elsewhere with sampling dates between 24 December 2019 and 3 February 2020 were analyzed. To explore the potential intermediate animal host of the SARS-CoV-2 virus, we reanalyzed virome data sets from pangolins and representative SARS-related coronaviruses isolates from bats, with particular attention paid to the spike glycoprotein gene. We performed phylogenetic, split network, transmission network, likelihood-mapping, and comparative analyses of the genomes."
Title: Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals Authors: Alba Grifoni, Daniela Weiskopf, Sydney Ramirez, Jose Mateus, Jennifer M. Dan, Carolyn Rydyznski Moderbacher), Stephen A. Rawlings, Aaron Sutherland, Lakshmanane Premkumar, Ramesh S. Jadi, Daniel Marrama, Aravinda M. de Silva, April Frazier, Aaron F. Carlin, Jason A. Greenbaum, Bjoern Peters, Florian Krammer, Davey M. Smith, Shane Crotty, Alessandro Sette Times cited: 783
Abstract: "Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic control measures. Using HLA class I and II predicted peptide 'megapools,' circulating SARS-CoV-2-specific CD8(+) and CD4(+) T cells were identified in similar to 70% and 100% of COVID-19 convalescent patients, respectively."
Title: A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV Authors: Meng Yuan, Nicholas C. Wu, Xueyong Zhu, Chang-Chun D. Lee, Ray T. Y. So, Huibin Lv, Chris K. P. Mok, Ian A. Wilson Times cited: 400
Abstract: "The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has now become a pandemic, but there is currently very little understanding of the antigenicity of the virus. We therefore determined the crystal structure of CR3022, a neutralizing antibody previously isolated from a convalescent SARS patient, in complex with the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) protein at 3.1-angstrom resolution ... These results provide molecular insights into antibody recognition of SARS-CoV-2."
Title: Prevalence of Asymptomatic SARS-CoV-2 Infection A Narrative Review Authors: Daniel P. Oran, Eric J. Topol Times cited: 395
Abstract: "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly throughout the world since the first cases of coronavirus disease 2019 (COVID-19) were observed in December 2019 in Wuhan, China. It has been suspected that infected persons who remain asymptomatic play a significant role in the ongoing pandemic, but their relative number and effect have been uncertain. The authors sought to review and synthesize the available evidence on asymptomatic SARS-CoV-2 infection."